| Autor: |
Antonov IB; St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia., Kozlov KL; St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia., Pal'tseva EM; B. V. Petrovsky Russian Surgery Research Center, Moscow, Russia., Polyakova OV; D. O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology, St. Petersburg, Russia., Lin'kova NS; St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia. miayy@yandex.ru.; Peter the Great St. Petersburg State Polytechnic University, St. Petersburg, Russia. miayy@yandex.ru. |
| Jazyk: |
angličtina |
| Zdroj: |
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2018 Mar; Vol. 164 (4), pp. 550-553. Date of Electronic Publication: 2018 Mar 05. |
| DOI: |
10.1007/s10517-018-4030-0 |
| Abstrakt: |
We studied the expression of MMP-2, MMP-9, and inhibitor TIMP-1 in myocardial autopsy samples from subjects of different age and in cardiomyocyte cultures in the norm and in dilated cardiomyopathy. In autopsy samples of normal myocardium and in cardiomyocyte cultures, expression of molecules involved in extracellular matrix remodeling did not change during aging. In dilation cardiomyopathy, expression of MMP-2, MMP-9, and TIMP-1 and their ratios in autopsy material and in cultures was elevated by 1.5-9 times. Remodeling of extracellular matrix plays an important role in the pathogenesis of dilated cardiomyopathy. MMP-2, MMP-9, and their inhibitor TIMP-1 and the MMP/TIMP ratios can be regarded as promising predictors of dilated cardiomyopathy and used for evaluation of the effectiveness of treatment of this conditions in patients of different ages. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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