Survival of Mesenchymal Stem Cells in Different Methods of Nebulization.

Autor: Aver'yanov AV; Research Institute of Pulmonology, Federal Biomedical Agency, Moscow, Russia. averyanovav@mail.ru., Konoplyannikov AG; National Medical Radiology Research Center, Ministry of Health of the Russian Federation, Obninsk, Russia., Antonov NS; Research Institute of Pulmonology, Federal Biomedical Agency, Moscow, Russia., Osipova GL; Research Institute of Pulmonology, Federal Biomedical Agency, Moscow, Russia., Vasil'eva OS; Research Institute of Pulmonology, Federal Biomedical Agency, Moscow, Russia., Sakharova MG; Research Institute of Pulmonology, Federal Biomedical Agency, Moscow, Russia., Tatarskii AR; Research Institute of Pulmonology, Federal Biomedical Agency, Moscow, Russia., Kobylyansky VI; Research Institute of Pulmonology, Federal Biomedical Agency, Moscow, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2018 Mar; Vol. 164 (4), pp. 576-578. Date of Electronic Publication: 2018 Mar 05.
DOI: 10.1007/s10517-018-4034-9
Abstrakt: We compared survival of bone marrow mesenchymal stem cells after compressor, ultrasound, and mesh nebulization of the cell suspension over 10 min. Viability of stromal cells was best preserved after compressor nebulization (72%). Cell survival after ultrasonic nebulization was significantly lower (20%). After mesh nebulization, no live cells were found. Thus, compressor nebulization is the most preferable method of the production of cell aerosol for their delivery to the lower respiratory tract.
Databáze: MEDLINE
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