| Autor: |
Zhidkova OV; Institute of Medicobiological Problems, Russian Academy of Sciences, Moscow, Russia., Andreeva ER; Institute of Medicobiological Problems, Russian Academy of Sciences, Moscow, Russia., Buravkova LB; Institute of Medicobiological Problems, Russian Academy of Sciences, Moscow, Russia. buravkova@imbp.ru. |
| Jazyk: |
angličtina |
| Zdroj: |
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2018 Mar; Vol. 164 (4), pp. 453-455. Date of Electronic Publication: 2018 Mar 05. |
| DOI: |
10.1007/s10517-018-4010-4 |
| Abstrakt: |
The studied the expression of intercellular adhesion molecules and transcription of the corresponding genes in intact and activated endothelial cells both in monoculture and during interaction with mesenchymal stromal cells. It was found that the levels of integrin-α1 and VE-cadherin mRNA increased during co-culturing. TNFα-induced activation of endothelial cells enhanced expression of integrin-α1 both at the mRNA and protein synthesis stages and had no effect on the level of VE-cadherin. Direct contact with mesenchymal stromal cells did not eliminate the effect of endothelial cell activation, but expression of integrin-α1 and VE-cadherin in activated endothelial cells tended to decrease. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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