The impact of overdiagnosis on thyroid cancer epidemic in Italy,1998-2012.

Autor: Dal Maso L; Cancer Epidemiology Unit, CRO Aviano National Cancer Institute IRCCS, Aviano, Italy. Electronic address: epidemiology@cro.it., Panato C; Cancer Epidemiology Unit, CRO Aviano National Cancer Institute IRCCS, Aviano, Italy., Franceschi S; International Agency for Research on Cancer, Lyon, France., Serraino D; Cancer Epidemiology Unit, CRO Aviano National Cancer Institute IRCCS, Aviano, Italy., Buzzoni C; Tuscany Cancer Registry, Clinical and Descriptive Epidemiology Unit, Cancer Prevention and Research Institute (ISPO), Florence, Italy; AIRTUM Database, Florence, Italy., Busco S; Cancer Registry of Latina Province, ASL Latina, Italy., Ferretti S; Ferrara Cancer Registry, University of Ferrara, Azienda USL Ferrara, Italy., Torrisi A; Registro Tumori Integrato Catania-Messina-Siracusa-Enna, Università Degli Studi di Catania, Italy., Falcini F; Romagna Cancer Registry, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola (Forlì), Italy-Azienda Usl della Romagna, Forlì, Italy., Zorzi M; Veneto Tumor Registry, Veneto Region, Padua, Italy., Cirilli C; Modena Cancer Registry, Public Health Department, AUSL Modena, Italy., Mazzucco W; Palermo and Province Cancer Registry, Clinical Epidemiology Unit with Cancer Registry, Azienda Ospedaliera Universitaria Policlinico 'Paolo Giaccone', University of Palermo, Italy., Magoni M; Brescia Cancer Registry, Epidemiology Unit, Brescia Health Protection Agency, Italy., Collarile P; Cancer Epidemiology Unit, CRO Aviano National Cancer Institute IRCCS, Aviano, Italy., Pannozzo F; Cancer Registry of Latina Province, ASL Latina, Italy., Caiazzo AL; ASL Salerno Cancer Registry, Salerno, Italy., Russo AG; Cancer Registry of Milan, Epidemiology Unit, Agency for Health Protection of Milan, Italy., Gili A; Public Health Section, Dept. of Experimental Medicine, University of Perugia, Italy., Caldarella A; Tuscany Cancer Registry, Clinical and Descriptive Epidemiology Unit, Cancer Prevention and Research Institute (ISPO), Florence, Italy., Zanetti R; Piedmont Cancer Registry, City of Torino, Ospedale S. Giovanni Battista-CPO, Torino, Italy., Michiara M; Parma Cancer Registry, Oncology Unit, Azienda Ospedaliera Universitaria di Parma, Italy., Mangone L; Reggio Emilia Cancer Registry, Epidemiology Unit, AUSL ASMN-IRCCS, Azienda USL di Reggio Emilia, Italy., Filiberti RA; Liguria Region Cancer Registry, Epidemiologia Clinica, Ospedale Policlinico San Martino IRCCS, Genova, Italy., Fusco M; Cancer Registry of ASL Napoli 3 Sud, Napoli, Italy., Gasparini F; Ferrara Cancer Registry, University of Ferrara, Azienda USL Ferrara, Italy., Tagliabue G; Lombardy Cancer Registry, Varese Province, Cancer Registry Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Cesaraccio R; North Sardinia Cancer Registry, Azienda Regionale per la Tutela della Salute, Sassari, Italy., Tumino R; Cancer Registry and Histopathology Department, 'Civic - M.P. Arezzo' Hospital, ASP Ragusa, Italy., Gatti L; Mantova Cancer Registry, Epidemilogy Unit, Agenzia di Tutela Della Salute (ATS) Della Val Padana, Mantova, Italy., Tisano F; Cancer Registry of the Province of Siracusa, Local Health Unit of Siracusa, Italy., Piffer S; Trento Province Cancer Registry, Unit of Clinical Epidemiology, Trento, Italy., Sini GM; Nuoro Cancer Registry, RT Nuoro, ASSL Nuoro/ATS Sardegna, Nuoro, Italy., Mazzoleni G; Southtyrol Cancer Registry, Bolzano, Italy., Rosso S; Piedmont Cancer Registry, Biella Province, Biella, Italy., Fanetti AC; Sondrio Cancer Registry, Health Protection Agency, Sondrio, Italy., Vaccarella S; International Agency for Research on Cancer, Lyon, France.
Jazyk: angličtina
Zdroj: European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2018 May; Vol. 94, pp. 6-15. Date of Electronic Publication: 2018 Mar 20.
DOI: 10.1016/j.ejca.2018.01.083
Abstrakt: Aims: In Italy, incidence rates of thyroid cancer (TC) are among the highest worldwide with substantial intracountry heterogeneity. The aim of the study was to examine time trends of TC incidence in Italy and to estimate the proportion of TC cases potentially attributable to overdiagnosis.
Methods: Data on TC cases reported to Italian cancer registries during 1998-2012 aged <85 years were included. Age-standardised incidence rates (ASR) were computed by sex, period, and histology. TC overdiagnosis was estimated by sex, period, age, and Italian region.
Results: In Italy between 1998-2002 and 2008-2012, TC ASR increased of 74% in women (from 16.2 to 28.2/100,000) and of 90% in men (from 5.3 to 10.1/100,000). ASR increases were nearly exclusively due to papillary TC (+91% in women, +120% in men). In both sexes, more than three-fold differences emerged between regions with highest and lowest ASR. Among TC cases diagnosed in 1998-2012 in Italy, we estimated that overdiagnosis accounted for 75% of cases in women and 63% in men and increased over the study period leading to overdiagnosis of 79% in women and 67% in men in 2008-2012. Notably, overdiagnosis was over 80% among women aged <55 years, and substantial variations were documented across Italian regions, in both genders.
Conclusion(s): Incidence rates of TC are steadily increasing in Italy and largely due to overdiagnosis. These findings call for an update of thyroid gland examination practices in the asymptomatic general population, at national and regional levels.
(Copyright © 2018 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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