| Autor: |
Bongert M; Department of Mechanical Engineering, Research Center for BioMedical Technology (BMT), University of Applied Sciences and Arts Dortmund, Sonnenstr. 96, D-44139 Dortmund, Germany, Phone: +49 231 9112 232, Fax: +49 231 9112 696., Geller M; Center of Research in Biomedical Engineering, University of Applied Sciences and Arts Dortmund, 44139 Dortmund, Germany., Pennekamp W; Institute for Radiological Diagnostics, Interventional Radiology and Nuclear Medicine, University Hospital Bergmannsheil, Ruhr-University Bochum, 44789 Bochum, Germany., Nicolas V; Institute for Radiological Diagnostics, Interventional Radiology and Nuclear Medicine, University Hospital Bergmannsheil, Ruhr-University Bochum, 44789 Bochum, Germany. |
| Abstrakt: |
Diseases of the cardiovascular system account for nearly 42% of all deaths in the European Union. In Germany, approximately 12,000 patients receive surgical replacement of the aortic valve due to heart valve disease alone each year. A three-dimensional (3D) numerical model based on patient-specific anatomy derived from four-dimensional (4D) magnetic resonance imaging (MRI) data was developed to investigate preoperatively the flow-induced impact of mounting positions of aortic prosthetic valves to select the best orientation for individual patients. Systematic steady-state analysis of blood flow for different rotational mounting positions of the valve is only possible using a virtual patient model. A maximum velocity of 1 m/s was used as an inlet boundary condition, because the opening angle of the valve is at its largest at this velocity. For a comparative serial examination, it is important to define the standardised general requirements to avoid impacts other than the rotated implantation of the prosthetic aortic valve. In this study, a uniform velocity profile at the inlet for the inflow of the aortic valve and the real aortic anatomy were chosen for all simulations. An iterative process, with the weighted parameters flow resistance (1), shear stress (2) and velocity (3), was necessary to determine the best rotated orientation. Blood flow was optimal at a 45° rotation from the standard implantation orientation, which will offer a supply to the coronary arteries. |
