NMDA or 5-HT receptor antagonists impair memory reconsolidation and induce various types of amnesia.

Autor: Nikitin VP; P.K. Anokhin Institute of Normal Physiology, Moscow, Russian Federation. Electronic address: vpnikitin48@gmail.com., Solntseva SV; P.K. Anokhin Institute of Normal Physiology, Moscow, Russian Federation., Kozyrev SA; P.K. Anokhin Institute of Normal Physiology, Moscow, Russian Federation., Nikitin PV; P.K. Anokhin Institute of Normal Physiology, Moscow, Russian Federation; Burdenko Neurosurgical Institute, Moscow, Russian Federation., Shevelkin AV; Department of Psychiatry and Behavioral Sciences, John Hopkins University School of Medicine, Baltimore, MD.
Jazyk: angličtina
Zdroj: Behavioural brain research [Behav Brain Res] 2018 Jun 01; Vol. 345, pp. 72-82. Date of Electronic Publication: 2018 Feb 27.
DOI: 10.1016/j.bbr.2018.02.036
Abstrakt: Elucidation of amnesia mechanisms is one of the central problems in neuroscience with immense practical application. Previously, we found that conditioned food presentation combined with injection of a neurotransmitter receptor antagonist or protein synthesis inhibitor led to amnesia induction. In the present study, we investigated the time course and features of two amnesias: induced by impairment of memory reconsolidation using an NMDA glutamate receptor antagonist (MK-801) and a serotonin receptor antagonist (methiothepin, MET) on snails trained with food aversion conditioning. During the early period of amnesia (<10th day), the unpaired presentation of conditioned stimuli (CS) or unconditioned stimuli (US) in the same training context did not have an effect on both types of amnesia. Retraining an on 1st or 3rd day of amnesia induction facilitated memory formation, i.e. the number of CS + US pairings was lower than at initial training. On the 10th or 30th day after the MET/reminder, the number of CS + US pairings did not change between initial training and retraining. Retraining on the 10th or 30th day following the MK-801/reminder in the same or a new context of learning resulted in short, but not long-term, memory, and the number of CS + US pairings was higher than at the initial training. This type of amnesia was specific to the CS we used at initial training, since long-term memory for another kind of CS could be formed in the same snails. The attained results suggest that disruption of memory reconsolidation using antagonists of serotonin or NMDA glutamate receptors induced amnesias with different abilities to form long-term memory during the late period of development.
(Copyright © 2018 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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