| Autor: |
Lammer AD; Department of Chemistry , The University of Texas at Austin , 105 East 24th Street, Stop A5300 , Austin , Texas 78712-1224 , United States., Thiabaud G; Department of Chemistry , The University of Texas at Austin , 105 East 24th Street, Stop A5300 , Austin , Texas 78712-1224 , United States., Brewster JT 2nd; Department of Chemistry , The University of Texas at Austin , 105 East 24th Street, Stop A5300 , Austin , Texas 78712-1224 , United States., Alaniz J; Department of Chemistry , The University of Texas at Austin , 105 East 24th Street, Stop A5300 , Austin , Texas 78712-1224 , United States., Bender JA; Department of Chemistry , The University of Texas at Austin , 105 East 24th Street, Stop A5300 , Austin , Texas 78712-1224 , United States., Sessler JL; Department of Chemistry , The University of Texas at Austin , 105 East 24th Street, Stop A5300 , Austin , Texas 78712-1224 , United States. |
| Abstrakt: |
Here, we report the use of gadolinium(III)-, lutetium(III)-, and lanthanum(III)-texaphyrins as bioinspired photocatalysts that promote a novel approach to the degradation of curcumin, a 1,3-diketo-containing natural product. Complexation of curcumin to the lanthanide centers of the texaphyrins yields stable species that display limited reactivity in the dark or under anaerobic conditions. However, upon exposure to mWatt intensity light (pocket flashlight) or simply under standard laboratory illumination in the presence of atmospheric oxygen, substrate oxidation occurs readily to generate curcumin-derived cleavage products. These latter species were identified on the basis of spectroscopic and mass spectrometric analyses. The mild nature of the activation conditions serves to highlight a potential new role for photoactive lanthanide complexes. |
