Systemic Inflammation in Severe Obese Patients Undergoing Surgery for Obesity and Weight-Related Diseases.

Autor: Freitas WR Jr; Master's Degree and PhD Post Graduation Program in Research in Surgery, Santa Casa of Sao Paulo Medical School, Sao Paulo, SP, Brazil., Oliveira LVF; School of Medicine, University Center of Anapolis (UniEvangélica), Rua Graciano A. de Souza 514, Lote 28, Quadra 07, Setor Bougainville, Anapolis, GO, 75075-580, Brazil. oliveira.lvf@pq.cnpq.br., Perez EA; Master's Degree and PhD Post Graduation Program in Research in Surgery, Santa Casa of Sao Paulo Medical School, Sao Paulo, SP, Brazil., Ilias EJ; Master's Degree and PhD Post Graduation Program in Research in Surgery, Santa Casa of Sao Paulo Medical School, Sao Paulo, SP, Brazil., Lottenberg CP; School of Health Sciences, Santa Casa de Sao Paulo, Sao Paulo, SP, Brazil., Silva AS; Sleep Laboratory, Master's Degree and PhD Programs in Rehabilitation Sciences, Nove de Julho University (UNINOVE), Sao Paulo, SP, Brazil., Urbano JJ; Sleep Laboratory, Master's Degree and PhD Programs in Rehabilitation Sciences, Nove de Julho University (UNINOVE), Sao Paulo, SP, Brazil., Oliveira MC Jr; Immunology and Pulmonary Exercise Laboratory, Master's Degree and PhD Program in Rehabilitation Sciences, Nove de Julho University (UNINOVE), Sao Paulo, SP, Brazil., Vieira RP; Universidade Brasil, Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE), Sao Jose dos Campos, SP, Brazil., Ribeiro-Alves M; Evandro Chagas Research Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil., Alves VLS; Master's Degree and PhD Post Graduation Program in Research in Surgery, Santa Casa of Sao Paulo Medical School, Sao Paulo, SP, Brazil., Kassab P; Master's Degree and PhD Post Graduation Program in Research in Surgery, Santa Casa of Sao Paulo Medical School, Sao Paulo, SP, Brazil., Thuler FR; Master's Degree and PhD Post Graduation Program in Research in Surgery, Santa Casa of Sao Paulo Medical School, Sao Paulo, SP, Brazil., Malheiros CA; Master's Degree and PhD Post Graduation Program in Research in Surgery, Santa Casa of Sao Paulo Medical School, Sao Paulo, SP, Brazil.
Jazyk: angličtina
Zdroj: Obesity surgery [Obes Surg] 2018 Jul; Vol. 28 (7), pp. 1931-1942.
DOI: 10.1007/s11695-017-3104-9
Abstrakt: Background: Obesity is a worldwide disease related to genetic, environmental, and behavioral factors, and it is associated with high rates of morbidity and mortality. Recently, obesity has been characterized by a low-grade inflammatory state known as inflammome indicated by chronic increases in circulating concentrations of inflammatory markers. The purpose of this study was to evaluate the effect of weight loss induced by surgery for obesity and weight-related diseases on pro-inflammatory cytokine (TNF-α) and anti-inflammatory adipokine (adiponectin) levels, and on an adipose-derived hormone (leptin) in severely obese subjects.
Methods: This randomized, controlled trial involved 55 severe obese patients (50 women, age 18-63 years, and body mass index of 35.7-63 kg/m 2 ) who underwent bariatric surgery (BS). Patients with a BMI > 65 kg/m 2 and clinical and mental instability, or significant and unrealistic expectations of surgery were excluded. Blood samples were collected during the fasting period to analyze tumor necrosis factor alpha (TNF-α), adiponectin, and leptin levels by enzyme-linked immunosorbent assay.
Results: At baseline, no significant difference was observed in the anthropometric, demographic, clinical characteristics and biochemistry and inflammatory markers between the control group (CG) and bariatric surgery group (BSG). The same finding was also observed when we compared the baseline variables to those at the 6-month follow-up in the CG. However, the same variables in the BSG group were significantly different between baseline and the 6-month follow-up after BS.
Conclusions: Weight loss induced by surgery for obesity and weight-related diseases reduced the inflammome state in severely obese patients.
Databáze: MEDLINE
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