Molecular Epidemiology of Helicobacter pylori Infection in a Minor Ethnic Group of Vietnam: A Multiethnic, Population-Based Study.

Autor: Binh TT; Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu-City, Oita 879-5593, Japan. bs.binh@yahoo.com.vn.; Department of Endoscopy, Cho Ray Hospital, Ho Chi Minh, Vietnam. bs.binh@yahoo.com.vn., Tuan VP; Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu-City, Oita 879-5593, Japan. vophuoctuandr@gmail.com.; Department of Endoscopy, Cho Ray Hospital, Ho Chi Minh, Vietnam. vophuoctuandr@gmail.com., Dung HDQ; Department of Endoscopy, Cho Ray Hospital, Ho Chi Minh, Vietnam. quydung@gmail.com., Tung PH; Department of Endoscopy, Cho Ray Hospital, Ho Chi Minh, Vietnam. quydung1@gmail.com., Tri TD; Department of Endoscopy, Cho Ray Hospital, Ho Chi Minh, Vietnam. trantri73@gmail.com., Thuan NPM; Department of Endoscopy, Cho Ray Hospital, Ho Chi Minh, Vietnam. minhthuan1177@yahoo.com., Tam LQ; Department of Endoscopy, Daklak Hospital, Daklak, Vietnam. quangpool@gmail.com., Nam BC; Department of Endoscopy, Lao Cai Hospital, Lao Cai, Vietnam. namlaocaihp1@gmail.com., Giang DA; Department of Endoscopy, Bach Mai Hospital, Hanoi, Vietnam. bsygiang@yahoo.com., Hoan PQ; Department of Molecular Biology, 108 Military Central Hospital, Hanoi, Vietnam. phan_hoan2002@yahoo.com., Uchida T; Department of Molecular Pathology, Oita University Faculty of Medicine, Yufu, Oita 879-5593, Japan. tomohisa@oita-u.ac.jp., Trang TTH; Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu-City, Oita 879-5593, Japan. huyentrang110@yahoo.com.; Department of Molecular Biology, 108 Military Central Hospital, Hanoi, Vietnam. huyentrang110@yahoo.com., Khien VV; Department of Hepatogastroenterology, 108 Military Central Hospital, Hanoi, Vietnam. vuvankhien108@yahoo.com.vn., Yamaoka Y; Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu-City, Oita 879-5593, Japan. yyamaoka@oita-u.ac.jp.; Department of Medicine, Gastroenterology and Hepatology Section, Baylor College of Medicine, Houston, TX 77030, USA. yyamaoka@oita-u.ac.jp.
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2018 Mar 01; Vol. 19 (3). Date of Electronic Publication: 2018 Mar 01.
DOI: 10.3390/ijms19030708
Abstrakt: The Helicobacter pylori -induced burden of gastric cancer varies based on geographical regions and ethnic grouping. Vietnam is a multiethnic country with the highest incidence of gastric cancer in Southeast Asia, but previous studies focused only on the Kinh ethnic group. A population-based cross-sectional study was conducted using 494 volunteers (18-78 years old), from 13 ethnic groups in Daklak and Lao Cai provinces, Vietnam. H. pylori status was determined by multiple tests (rapid urease test, culture, histology, and serology). cagA and vacA genotypes were determined by PCR-based sequencing. The overall H. pylori infection rate was 38.1%. Multivariate analysis showed that variations in geographical region, age, and ethnicity were independent factors associated with the risk of H. pylori acquisition. Therefore, multicenter, multiethnic, population based study is essential to assess the H. pylori prevalence and its burden in the general population. Only the E De ethnicity carried strains with Western-type CagA (82%) and exhibited significantly lower gastric mucosal inflammation compared to other ethnic groups. However, the histological scores of Western-type CagA and East-Asian-type CagA within the E De group showed no significant differences. Thus, in addition to bacterial virulence factors, host factors are likely to be important determinants for gastric mucosal inflammation and contribute to the Asian enigma.
Competing Interests: All authors declare that they have no potential conflicts of interest.
Databáze: MEDLINE
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