Ultrasound in Prenatal Diagnostics and Its Impact on the Epidemiology of Spina Bifida in a National Cohort from Denmark with a Comparison to Sweden.

Autor: Bodin CR; Department of Gynecology and Obstetrics, Aarhus University Hospital, Aarhus, Denmark., Rasmussen MM; Department of Neurosurgery, Aarhus University Hospital, Aarhus, Denmark., Tabor A; Center of Fetal Medicine, Department of Obstetrics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Westbom L; Section of Pediatrics, Department of Clinical Sciences Lund, Faculty of Medicine, Skåne University Hospital, Lund University, Lund, Sweden., Tiblad E; Department of Fetal Medicine, Karolinska University Hospital, Stockholm, Sweden., Ekelund CK; Center of Fetal Medicine, Department of Obstetrics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Wulff CB; Center of Fetal Medicine, Department of Obstetrics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Vogel I; Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark.; Center for Prenatal Diagnostics, Aarhus University Hospital, Aarhus, Denmark., Petersen OB; Department of Gynecology and Obstetrics, Aarhus University Hospital, Aarhus, Denmark.; Center for Prenatal Diagnostics, Aarhus University Hospital, Aarhus, Denmark.
Jazyk: angličtina
Zdroj: BioMed research international [Biomed Res Int] 2018 Feb 01; Vol. 2018, pp. 9203985. Date of Electronic Publication: 2018 Feb 01 (Print Publication: 2018).
DOI: 10.1155/2018/9203985
Abstrakt: Objectives: The aim of this study was to assess the incidence, the prenatal detection rate by ultrasound, and the pregnancy outcome of spina bifida (SB) in Denmark (DK) in 2008-2015 and to compare results to national data from Sweden.
Methods: Data were retrieved from the Danish Fetal Medicine Database, which includes International Classification of Diseases- (ICD-) 10 codes for pre- or postnatally diagnoses and pregnancy outcome. Missing data were obtained from the National Patient Register. Livebirth data with myelomeningocele (MMC) in Sweden were obtained from different databases.
Results: There were 234 cases with SB in DK in 2008-2015. The incidence of SB was 4.9 : 10,000; 89% were detected with ultrasound prior to week 22; 90% of these pregnancies were terminated (ToP); 91% were isolated malformations of which 11% showed abnormal karyotype. The incidence of newborns with MMC was 1.3 : 10,000 in Sweden.
Conclusions: Ultrasound screening has a major impact on the epidemiology of SB. The prenatal detection rate of SB was high, and most SB cases were isolated and had a normal karyotype. Among women with a prenatal fetal diagnosis of SB, 90% chose to have ToP. The incidence of newborns with SB was higher in Sweden than in DK.
Databáze: MEDLINE
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