Non-invasive assessment of coronary artery geometry using coronary CTA.

Autor: Tuncay V; University of Groningen, University Medical Center Groningen, Center for Medical Imaging - North East Netherlands (CMI-NEN), Department of Radiology, The Netherlands., Vliegenthart R; University of Groningen, University Medical Center Groningen, Center for Medical Imaging - North East Netherlands (CMI-NEN), Department of Radiology, The Netherlands; University of Groningen, University Medical Center Groningen, Department of Radiology, The Netherlands., den Dekker MAM; University of Groningen, University Medical Center Groningen, Center for Medical Imaging - North East Netherlands (CMI-NEN), Department of Radiology, The Netherlands; University of Groningen, University Medical Center Groningen, Department of Radiology, The Netherlands., de Jonge GJ; University of Groningen, University Medical Center Groningen, Department of Radiology, The Netherlands., van Zandwijk JK; University of Groningen, University Medical Center Groningen, Center for Medical Imaging - North East Netherlands (CMI-NEN), Department of Radiology, The Netherlands; University of Twente, Technical Medicine Faculty, The Netherlands., van der Harst P; University of Groningen, University Medical Center Groningen, Cardiology, The Netherlands., Oudkerk M; University of Groningen, University Medical Center Groningen, Center for Medical Imaging - North East Netherlands (CMI-NEN), Department of Radiology, The Netherlands., van Ooijen PMA; University of Groningen, University Medical Center Groningen, Center for Medical Imaging - North East Netherlands (CMI-NEN), Department of Radiology, The Netherlands; University of Groningen, University Medical Center Groningen, Department of Radiology, The Netherlands. Electronic address: p.m.a.van.ooijen@umcg.nl.
Jazyk: angličtina
Zdroj: Journal of cardiovascular computed tomography [J Cardiovasc Comput Tomogr] 2018 May - Jun; Vol. 12 (3), pp. 257-260. Date of Electronic Publication: 2018 Feb 19.
DOI: 10.1016/j.jcct.2018.02.003
Abstrakt: Aim: To assess the association of coronary artery geometry with the severity of coronary artery disease (CAD).
Methods: 73 asymptomatic individuals at increased risk of CAD due to peripheral vascular disease (18 women, mean age 63.5 ± 8.2 years) underwent coronary computed tomography angiography (coronary CTA) using first generation dual-source CT. Curvature and tortuosity of the coronary arteries were quantified using semi-automatically generated centerlines. Measurements were performed for individual segments and for the entire artery. Coronary segments were labeled according to the presence of significant stenosis, defined as >70% luminal narrowing, and the presence of plaque. Comparisons were made by segment and by artery, using linear mixed models.
Results: Overall, median curvature and tortuosity were, respectively, 0.094 [0.071; 0.120] and 1.080 [1.040; 1.120] on a per-segment level, and 0.096 [0.078; 0.118] and 1.175 [1.090; 1.420] on a per-artery level. Curvature was associated with significant stenosis at a per-segment (p < 0.001) and per-artery level (p = 0.002). Curvature was 16.7% higher for segments with stenosis, and 13.8% higher for arteries with stenosis. Tortuosity was associated with significant stenosis only at the per-segment level (p = 0.002). Curvature was related to the presence of plaque at the per-segment (p < 0.001) and per-artery level (p < 0.001), tortuosity was only related to plaque at the per-segment level (p < 0.001).
Conclusion: Coronary artery geometry as derived from coronary CTA is related to the presence of plaque and significant stenosis.
(Copyright © 2018 Society of Cardiovascular Computed Tomography. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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