Gastrointestinal tract and liver graft-versus-host disease in pediatric patients with hematopoietic progenitor cell transplantation at a tertiary care center in Mexico.

Autor:	Jaramillo-Esparza CM; Departamento de Gastroenterología y Nutrición, Hospital Infantil de México Federico Gómez, SSA, Ciudad de México, México., Consuelo-Sánchez A; Departamento de Gastroenterología y Nutrición, Hospital Infantil de México Federico Gómez, SSA, Ciudad de México, México., Acosta-Rodríguez-Bueno CP; Departamento de Gastroenterología y Nutrición, Hospital Infantil de México Federico Gómez, SSA, Ciudad de México, México., Ramón-García G; Departamento de Patología, Hospital Infantil de México Federico Gómez, SSA, Ciudad de México, México., Sadowinski-Pine SW; Departamento de Patología, Hospital Infantil de México Federico Gómez, SSA, Ciudad de México, México., Escobar-Sánchez MA; Departamento de Patología, Hospital Infantil de México Federico Gómez, SSA, Ciudad de México, México., Castorena-Villa I; Servicio de Trasplante de Médula Ósea, Hospital Infantil de México Federico Gómez, SSA, Ciudad de México, México., Gaytán-Morales F; Servicio de Trasplante de Médula Ósea, Hospital Infantil de México Federico Gómez, SSA, Ciudad de México, México., Vázquez-Frias R; Departamento de Gastroenterología y Nutrición, Hospital Infantil de México Federico Gómez, SSA, Ciudad de México, México. Electronic address: rovaf@yahoo.com.
Jazyk:	English; Spanish; Castilian
Zdroj:	Revista de gastroenterologia de Mexico (English) [Rev Gastroenterol Mex (Engl Ed)] 2018 Oct - Dec; Vol. 83 (4), pp. 385-392. Date of Electronic Publication: 2018 Feb 24.
DOI:	10.1016/j.rgmx.2017.10.002
Abstrakt:	Introduction and Aims: Graft-versus-host disease (GVHD) is a common multisystemic complication of allogeneic hematopoietic cell transplantation. The most frequent presentations of graft-versus-host disease involve the skin, the gastrointestinal tract, and the liver. The aim of the present study was to know the frequency of gastrointestinal tract and liver GVHD and the characteristics of disease presentation in pediatric patients that underwent hematopoietic stem cell transplantation (HSCT) at a tertiary care hospital center in Mexico City. Material and Methods: A retrospective study was carried out, utilizing the case records of patients that underwent HSCT in 2015, to determine the frequency of GVHD in pediatric patients at a Mexican tertiary care hospital center. Results: In 2015, 16 HSCT were performed, 11 of which were carried out in males (68%). Only 3 patients developed graft-versus-host disease (18.7%). One patient presented with skin and liver GVHD and 2 patients presented with gastrointestinal tract and liver GVHD, which was the most frequent type. Conclusions: HSCT is still an uncommon procedure in Mexico and there is a lower frequency of gastrointestinal tract and liver GVHD than that reported in other studies. Most certainly, there will be an increase in this type of patient and risk factors in the Mexican population must still be determined to help predict the onset of GVHD. (Copyright © 2018 Asociación Mexicana de Gastroenterología. Publicado por Masson Doyma México S.A. All rights reserved.)
Databáze:	MEDLINE
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