Lipophilicity evaluation of some thiazolyl-1,3,4-oxadiazole derivatives with antifungal activity.

Autor: Stoica CI; Department of Therapeutical Chemistry, Iuliu Haţieganu University of Medicine and Pharmacy, Faculty of Pharmacy, Cluj-Napoca, Romania., Ionuț I; Department of Pharmaceutical Chemistry, Iuliu Haţieganu University of Medicine and Pharmacy, Faculty of Pharmacy, Cluj-Napoca, Romania., Vlase L; Department of Pharmaceutical Technology and Biopharmaceutics, Iuliu Haţieganu University of Medicine and Pharmacy, Faculty of Pharmacy, Cluj-Napoca, Romania., Tiperciuc B; Department of Pharmaceutical Chemistry, Iuliu Haţieganu University of Medicine and Pharmacy, Faculty of Pharmacy, Cluj-Napoca, Romania., Marc G; Department of Pharmaceutical Chemistry, Iuliu Haţieganu University of Medicine and Pharmacy, Faculty of Pharmacy, Cluj-Napoca, Romania., Oniga S; Department of Therapeutical Chemistry, Iuliu Haţieganu University of Medicine and Pharmacy, Faculty of Pharmacy, Cluj-Napoca, Romania., Araniciu C; Department of Therapeutical Chemistry, Iuliu Haţieganu University of Medicine and Pharmacy, Faculty of Pharmacy, Cluj-Napoca, Romania., Oniga O; Department of Pharmaceutical Chemistry, Iuliu Haţieganu University of Medicine and Pharmacy, Faculty of Pharmacy, Cluj-Napoca, Romania.
Jazyk: angličtina
Zdroj: Biomedical chromatography : BMC [Biomed Chromatogr] 2018 Jul; Vol. 32 (7), pp. e4221. Date of Electronic Publication: 2018 Apr 02.
DOI: 10.1002/bmc.4221
Abstrakt: The chromatographic behavior of a series of thiazolyl-1,3,4-oxadiazoles with antifungal activity was studied by reverse-phase thin-layer chromatography (RP-TLC). The lipophilicity parameters derived from RP-TLC were correlated with the data derived from liquid-chromatography mass-spectrometry. Good linear relationships were observed between the chromatographic lipophilicity parameters and the theoretical lipophilicity descriptors (logP) generated by various computer software and internet modules. Principal component analysis, applied on the experimental chromatographic lipophilicity indices and the theoretically calculated logP, enabled us to obtain a lipophilicity chart for better vizualization of the similarities and differences of the investigated compounds, which were grouped by k-means clustering in two congeneric classes.
(Copyright © 2018 John Wiley & Sons, Ltd.)
Databáze: MEDLINE
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