A randomized triple-blind crossover trial of a hydrocolloid-containing dentifrice as a controlled-release system for fluoride.

Autor: Alves VF; Department of Clinical and Social Dentistry, Federal University of Paraiba, Castelo Branco, s/n., João Pessoa, Paraiba, 58051-900, Brazil. vanessafalves@hotmail.com., Moreira VG; Department of Clinical and Social Dentistry, Federal University of Paraiba, Castelo Branco, s/n., João Pessoa, Paraiba, 58051-900, Brazil., Soares AF; Department of Clinical and Social Dentistry, Federal University of Paraiba, Castelo Branco, s/n., João Pessoa, Paraiba, 58051-900, Brazil., de Albuquerque LS; Department of Clinical and Social Dentistry, Federal University of Paraiba, Castelo Branco, s/n., João Pessoa, Paraiba, 58051-900, Brazil., Moura HS; Department of Clinical and Social Dentistry, Federal University of Paraiba, Castelo Branco, s/n., João Pessoa, Paraiba, 58051-900, Brazil., de Oliveira Silva A; Lauro Wanderley University Hospital, Federal University of Paraiba, Castelo Branco, s/n., João Pessoa, Paraiba, 58051-900, Brazil., Sampaio FC; Department of Clinical and Social Dentistry, Federal University of Paraiba, Castelo Branco, s/n., João Pessoa, Paraiba, 58051-900, Brazil.
Jazyk: angličtina
Zdroj: Clinical oral investigations [Clin Oral Investig] 2018 Dec; Vol. 22 (9), pp. 3071-3077. Date of Electronic Publication: 2018 Feb 26.
DOI: 10.1007/s00784-018-2395-0
Abstrakt: Objective: To evaluate retention of intraoral fluoride in biofilm and saliva, an experimental dentifrice containing hydrocolloid (tara gum) was used as a controlled-release system for fluoride (F).
Materials and Methods: In a triple-blind randomized crossover trial with washout, 18 individuals used the following different dentifrices for a week: 100-TGF (sodium fluoride NaF associated with tara gum, 1100 mg/L), 50-TGF (50% NaF associated with tara gum + 50% free NaF, 1100 mg/L), PC (free NaF, 1100 mg/L), TG (with tara gum and without F), and placebo (without F or tara gum). On the seventh day of dentifrice use, biofilm was collected at 1 and 12 h, and saliva was collected up to 60 min and 12 h after the last toothbrushing. F concentrations were determined by physico-chemical analysis of fluoride using the hexamethyldisiloxane-facilitated diffusion technique. Data were subjected to two-way analysis of variance (repeated measures) and Spearman's correlation coefficient (p < 0.05) testing.
Results: No significant difference was observed with the same dentifrice regarding F retention in biofilm at 1 and 12 h after toothbrushing for the 100-TGF, placebo, and TG groups (p > 0.05). The highest area under the curve values in saliva were found for the 50-TGF, 100-TGF, and PC groups.
Conclusion: The dentifrice containing hydrocolloid as a controlled-release system for F promoted F retention in the oral cavity, even at 12 h after brushing.
Clinical Relevance: Hydrocolloid added to dentifrices as a controlled-release system for F might contribute to a higher anti-caries effect.
Trial Registration: NCT02809014.
Databáze: MEDLINE
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