Restorative effects of human neural stem cell grafts on the primate spinal cord.

Autor: Rosenzweig ES; Department of Neurosciences, University of California, San Diego, La Jolla, California, USA., Brock JH; Department of Neurosciences, University of California, San Diego, La Jolla, California, USA.; Veterans Administration Medical Center, La Jolla, California, USA., Lu P; Department of Neurosciences, University of California, San Diego, La Jolla, California, USA.; Veterans Administration Medical Center, La Jolla, California, USA., Kumamaru H; Department of Neurosciences, University of California, San Diego, La Jolla, California, USA., Salegio EA; California National Primate Research Center, University of California, Davis, Davis, California, USA., Kadoya K; Department of Neurosciences, University of California, San Diego, La Jolla, California, USA.; Department of Orthopaedic Surgery, Hokkaido University, Sapporo, Japan., Weber JL; Department of Neurosciences, University of California, San Diego, La Jolla, California, USA., Liang JJ; Department of Neurosciences, University of California, San Diego, La Jolla, California, USA., Moseanko R; California National Primate Research Center, University of California, Davis, Davis, California, USA., Hawbecker S; California National Primate Research Center, University of California, Davis, Davis, California, USA., Huie JR; Department of Neurosurgery, University of California, San Francisco, San Francisco, California, USA., Havton LA; Department of Neurology, University of California, Los Angeles, Los Angeles, California, USA., Nout-Lomas YS; College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA., Ferguson AR; Department of Neurosurgery, University of California, San Francisco, San Francisco, California, USA.; Veterans Administration Medical Center, San Francisco, California, USA., Beattie MS; Department of Neurosurgery, University of California, San Francisco, San Francisco, California, USA., Bresnahan JC; Department of Neurosurgery, University of California, San Francisco, San Francisco, California, USA., Tuszynski MH; Department of Neurosciences, University of California, San Diego, La Jolla, California, USA.; Veterans Administration Medical Center, La Jolla, California, USA.
Jazyk: angličtina
Zdroj: Nature medicine [Nat Med] 2018 May; Vol. 24 (4), pp. 484-490. Date of Electronic Publication: 2018 Feb 26.
DOI: 10.1038/nm.4502
Abstrakt: We grafted human spinal cord-derived neural progenitor cells (NPCs) into sites of cervical spinal cord injury in rhesus monkeys (Macaca mulatta). Under three-drug immunosuppression, grafts survived at least 9 months postinjury and expressed both neuronal and glial markers. Monkey axons regenerated into grafts and formed synapses. Hundreds of thousands of human axons extended out from grafts through monkey white matter and synapsed in distal gray matter. Grafts gradually matured over 9 months and improved forelimb function beginning several months after grafting. These findings in a 'preclinical trial' support translation of NPC graft therapy to humans with the objective of reconstituting both a neuronal and glial milieu in the site of spinal cord injury.
Databáze: MEDLINE
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