Changes and Clinical Consequences of Smoking Cessation in Patients With COPD: A Prospective Analysis From the CHAIN Cohort.
| Autor: | Martínez-González C; Department of Respiratory Medicine, Hospital Universitario Central de Asturias, Oviedo, Spain., Casanova C; Department of Respiratory Medicine, Hospital Universitario Nuestra Señora de Candelaria/Universidad de La Laguna, Tenerife, Spain., de-Torres JP; Department of Respiratory Medicine, Clínica Universidad de Navarra, Pamplona, Spain., Marín JM; Department of Respiratory Medicine, Hospital Universitario Miguel Servet-IISAragon, Zaragoza, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, CIBERES, Instituto de Salud Carlos III, Madrid, Spain., de Lucas P; Department of Respiratory Medicine, Hospital Gregorio Marañon, Fundación de Investigación Biomédica Gregorio Marañón, Madrid, Spain., Fuster A; Department of Respiratory Medicine, Hospital Son Llàtzer, Palma de Mallorca, Spain., Cosío BG; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, CIBERES, Instituto de Salud Carlos III, Madrid, Spain; Department of Respiratory Medicine, Hospital Universitario Son Espases-IdISBa-CIBERES, Palma de Mallorca, Spain., Calle M; Department of Respiratory Medicine, Hospital Clínico San Carlos, Madrid, Spain; Department of Medicine, Faculty of Medicine, Complutense University of Madrid, Madrid, Spain., Peces-Barba G; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, CIBERES, Instituto de Salud Carlos III, Madrid, Spain; Department of Respiratory Medicine, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain., Solanes I; Respiratory Department, Hospital de la Santa Creu y San Pau, Universidad Autónoma de Barcelona, Barcelona, Spain., Agüero R; Pulmonary Department, Hospital Universitario Marqués de Valdecilla, Santander, Spain., Feu-Collado N; Pulmonary Department, Hospital Universitario Reina Sofía, Instituto Maimónides de Investigación Biomédica de Córdoba, Universidad de Córdoba, Córdoba, Spain., Alfageme I; Pulmonary Department, Hospital Universitario de Valme/Universidad de Sevilla, Seville, Spain., Romero Plaza A; Pulmonary Department, Hospital de Manacor, Manacor, Islas Baleares, Spain., Balcells E; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, CIBERES, Instituto de Salud Carlos III, Madrid, Spain; Pulmonary Department, Hospital del Mar, Barcelona, Spain., de Diego A; Pulmonary Department, Hospital Universitario y Politécnico de la Fe, Valencia, Spain., Marín Royo M; Pulmonary Department, Hospital General de Castellón, Castellón, Spain., Moreno A; Pulmonary Department, Hospital Parc Taulí, Barcelona, Spain., Llunell Casanovas A; Pulmonary Department, Hospital de Tarrasa, Tarrasa, Spain., Galdiz JB; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, CIBERES, Instituto de Salud Carlos III, Madrid, Spain; Pulmonary Department, Hospital Universitario de Cruces, Bilbao, Spain., Golpe R; Pulmonary Department, Hospital Universitario Lucus Augusti, Lugo, Spain., Lacárcel Bautista C; Pulmonary Department, Hospital Ciudad de Jaén, Jaén, Spain., Cabrera C; Pulmonary Department, Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria, Spain., Marin A; Pulmonary Department, Hospital Universitario German Trias y Pujol, Barcelona, Spain., Soriano JB; Instituto de Investigación, Hospital Universitario de la Princesa (Instituto de Investigación Sanitaria del Hospital de la Princesa), Universidad Autónoma de Madrid, Madrid, Spain., Lopez-Campos JL; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, CIBERES, Instituto de Salud Carlos III, Madrid, Spain; Unidad Médico-Quirúrgica de Enfermedades Respiratorias, Hospital Universitario Virgen del Rocío/Universidad de Sevilla, Instituto de Biomedicina de Sevilla (IBiS)/ CIBERES, Seville, Spain. Electronic address: lcampos@separ.es. |
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| Jazyk: | angličtina |
| Zdroj: | Chest [Chest] 2018 Aug; Vol. 154 (2), pp. 274-285. Date of Electronic Publication: 2018 Feb 22. |
| DOI: | 10.1016/j.chest.2018.02.007 |
| Abstrakt: | Background: Despite the existing evidence-based smoking cessation interventions, chances of achieving that goal in real life are still low among patients with COPD. We sought to evaluate the clinical consequences of changes in smoking habits in a large cohort of patients with COPD. Methods: CHAIN (COPD History Assessment in Spain) is a Spanish multicenter study carried out at pulmonary clinics including active and former smokers with COPD. Smoking status was certified by clinical history and co-oximetry. Clinical presentation and disease impact were recorded via validated questionnaires, including the London Chest Activity of Daily Living (LCADL) and the Hospital Anxiety and Depression Scale (HADS). No specific smoking cessation intervention was carried out. Factors associated with and clinical consequences of smoking cessation were analyzed by multivariate regression and decision tree analyses. Results: One thousand and eighty-one patients with COPD were included (male, 80.8%; age, 65.2 [SD 8.9] years; FEV Conclusions: In this real-life prospective COPD cohort with no specific antismoking intervention, the majority of patients did not change their smoking status. Our study also identifies baseline expectoration, anxiety, and dyspnea with daily activities as the major determinants of smoking status in COPD. Trial Registry: ClinicalTrials.gov; No. NCT01122758; URL: www.clinicaltrials.gov. (Copyright © 2018 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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