The pedunculopontine and laterodorsal tegmental nuclei in the kainate model of epilepsy.

Autor:	Soares JI; Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal; Instituto de Biologia Molecular e Celular da Universidade do Porto, Porto, Portugal; Departamento de Biomedicina, Faculdade de Medicina da Universidade do Porto, Porto, Portugal; Programa Doutoral em Neurociências, Universidade do Porto, Porto, Portugal., Afonso AR; Departamento de Biomedicina, Faculdade de Medicina da Universidade do Porto, Porto, Portugal., Maia GH; Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal; Instituto de Biologia Molecular e Celular da Universidade do Porto, Porto, Portugal; Departamento de Biomedicina, Faculdade de Medicina da Universidade do Porto, Porto, Portugal; Medibrain-Centro de Estudos Neurofisiológicos, Vila do Conde, Portugal., Lukoyanov NV; Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal; Instituto de Biologia Molecular e Celular da Universidade do Porto, Porto, Portugal; Departamento de Biomedicina, Faculdade de Medicina da Universidade do Porto, Porto, Portugal; Medibrain-Centro de Estudos Neurofisiológicos, Vila do Conde, Portugal. Electronic address: luk@med.up.pt.
Jazyk:	angličtina
Zdroj:	Neuroscience letters [Neurosci Lett] 2018 Apr 13; Vol. 672, pp. 90-95. Date of Electronic Publication: 2018 Feb 21.
DOI:	10.1016/j.neulet.2018.02.044
Abstrakt:	Prior studies showed that epilepsy can be associated with reorganization of the septohippocampal cholinergic fiber system. Using the kainate model of epilepsy, we wished to further examine the structural integrity of the mesopontine tegmental nuclei (pedunculopontine, PPN, and laterodorsal, LDT), which provide the cholinergic input to the thalamus. It was found that the total numbers of the PPN and LDT cells immunoreactive to the vesicular acetylcholine transporter did not differ between control and epileptic rats. However, the cholinergic cells had enlarged perikarya in epileptic rats. We further examined the effects of epilepsy on the distribution pattern of cholinergic fiber varicosities in the parafascicular nucleus, one of the principal thalamic targets of PPN projections. The density of cholinergic varicosities, represented by two distinct populations, was increased in epileptic rats. These data provide the first morphological evidence for structural alterations in mesopontine cholinergic neurons in experimental epilepsy. They suggest dysfunctional cholinergic transmission in the brainstem-thalamic pathway, which may partly account for various epilepsy-related neurological disturbances. (Copyright © 2018 Elsevier B.V. All rights reserved.)
Databáze:	MEDLINE
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