Ageing effects on humoral immune responses in chronic periodontitis.

Autor: Ebersole JL; Department of Biomedical Sciences, School of Dental Medicine, University of Nevada Las Vegas, Las Vegas, NV, USA.; Center for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, KY, USA., Al-Sabbagh M; Division of Periodontology, College of Dentistry, University of Kentucky, Lexington, KY, USA., Gonzalez OA; Center for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, KY, USA.; Division of Periodontology, College of Dentistry, University of Kentucky, Lexington, KY, USA., Dawson DR 3rd; Center for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, KY, USA.; Division of Periodontology, College of Dentistry, University of Kentucky, Lexington, KY, USA.
Jazyk: angličtina
Zdroj: Journal of clinical periodontology [J Clin Periodontol] 2018 Jun; Vol. 45 (6), pp. 680-692. Date of Electronic Publication: 2018 Apr 26.
DOI: 10.1111/jcpe.12881
Abstrakt: Periodontal disease is a dominant global bacterial infection that increases with ageing.
Aim: This report focuses on host adaptive immune responses in periodontitis. While experimental models and humans diagnosed with periodontitis demonstrate an antigenic specificity for particular oral bacteria, we have a limited understanding of (i) how ageing affects the adaptive immune responses to these bacteria that chronically colonize the oral cavity for decades prior to disease expression and (ii) how the magnitude and specificity of the response interface with pathogens that emerge within the bacterial ecology during exacerbations of disease.
Materials and Methods: Serum antibody levels to a group of pathogenic and commensal oral bacteria were measured in a population of individuals from 21 to 74 years of age, stratified based on clinical status of the periodontium, smoking and sex.
Results: Clinical parameters were not significantly different within health, gingivitis or periodontitis groups related to age. Antibody to oral pathogens and commensals was similar in different age groups in each of the clinical categories, with no age correlation noted in the periodontitis patients.
Conclusions: The adaptive immune responses to oral bacteria that chronically colonize the oral cavity appear generally unaffected by age, but clearly are linked to the extent of disease.
(© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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