Differences in Urinary Amino Acid Patterns in Individuals with Different Types of Urological Tumor Urinary Amino Acid Patterns as Markers of Urological Tumors.

Autor:	Duskova K; Department of Urology, Second Faculty of Medicine, Charles University, and University Hospital Motol, Prague, Czech Republic katerina.duskova@fnmotol.cz., Vesely S; Department of Urology, Second Faculty of Medicine, Charles University, and University Hospital Motol, Prague, Czech Republic., DO Carmo Silva J; Department of Urology, Second Faculty of Medicine, Charles University, and University Hospital Motol, Prague, Czech Republic., Cernei N; Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic.; Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, Czech Republic., Zitka O; Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic.; Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, Czech Republic., Heger Z; Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic.; Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, Czech Republic., Adam V; Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic.; Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, Czech Republic., Havlova K; Department of Urology, Second Faculty of Medicine, Charles University, and University Hospital Motol, Prague, Czech Republic., Babjuk M; Department of Urology, Second Faculty of Medicine, Charles University, and University Hospital Motol, Prague, Czech Republic.
Jazyk:	angličtina
Zdroj:	In vivo (Athens, Greece) [In Vivo] 2018 Mar-Apr; Vol. 32 (2), pp. 425-429.
DOI:	10.21873/invivo.11257
Abstrakt:	Background: Insufficient specificity and invasiveness of currently used diagnostic methods raises the need for new markers of urological tumors. The aim of this study was to find a link between the urinary excretion of amino acids and the presence of urological tumors. Materials and Methods: Using ion-exchange chromatography, we tested urine samples of patients with prostate cancer (n=30), urinary bladder cancer (n=28), renal cell carcinoma (n=16) and healthy volunteers (control group; n=21). Results: In each category, we found a group of amino acids which differed in concentration compared to the control group. These differences were most significant in sarcosine in patients with prostate cancer; leucine, phenylalanine and arginine in those with bladder cancer; and sarcosine, glutamic acid, glycine, tyrosine and arginine in the those with renal cell carcinoma. Conclusion: Results of our research imply a possible connection between the occurrence of specific types of amino acids in the urine and the presence of urological tumors. (Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
Databáze:	MEDLINE
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