Lady Windermere syndrome in Castile and León.
Autor: | Blanco-Conde S; Servicio de Análisis Clínicos, Complejo Asistencial Universitario de León, León, España. Electronic address: sl.blanconde@gmail.com., Nebreda-Mayoral T; Servicio de Microbiología, Complejo Asistencial Universitario de León, León, España., Labayru-Echeverría C; Servicio de Microbiología, Complejo Asistencial Universitario de Burgos, Burgos, España., Brezmes-Valdivieso MF; Servicio de Microbiología, Complejo Asistencial de Zamora, Hospital Virgen de la Concha, Zamora, España., López-Medrano R; Unidad de Microbiología, Hospital El Bierzo, Ponferrada, León, España., Nogueira-González B; Servicio de Microbiología, Hospital Clínico Universitario de Valladolid, Valladolid, España. |
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Jazyk: | English; Spanish; Castilian |
Zdroj: | Enfermedades infecciosas y microbiologia clinica (English ed.) [Enferm Infecc Microbiol Clin (Engl Ed)] 2018 Dec; Vol. 36 (10), pp. 644-647. Date of Electronic Publication: 2018 Feb 19. |
DOI: | 10.1016/j.eimc.2017.12.008 |
Abstrakt: | Introduction: Lady Windermere syndrome (LWS) is a pulmonary disease caused by Mycobacterium avium complex (MAC). The objective of this study is to ascertain its frequency and characteristics in the northern area of the autonomous community of Castile and León. Methods: A retrospective study of patients with MAC isolates in respiratory samples from five public hospitals in the autonomous community over a six-year period, following the ATS/IDSA criteria. The MAC strains were identified by GenoType Mycobacterium reverse hybridisation probes or PCR-RFLP analysis of the hsp65 gene. Results: Of 183 cases of MAC identified, only five women (2.7%) aged 68.8±10.7years met LWS criteria. In three cases, MAC was isolated jointly and intermittently with other pathogens. Only one patient was treated according to ATS/IDSA criteria. Discussion: LWS remains underestimated, with affected patients representing a significant burden on healthcare resources over long periods of time. As a result, greater microbiological and therapeutic knowledge of the syndrome is needed. (Copyright © 2018 Elsevier España, S.L.U. and Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.) |
Databáze: | MEDLINE |
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