Heavy Cannabis Use Associated With Reduction in Activated and Inflammatory Immune Cell Frequencies in Antiretroviral Therapy-Treated Human Immunodeficiency Virus-Infected Individuals.

Autor:	Manuzak JA; Department of Pharmaceutics, University of Washington.; Washington National Primate Research Center., Gott TM; Department of Pharmaceutics, University of Washington.; Washington National Primate Research Center., Kirkwood JS; Department of Pharmaceutics, University of Washington., Coronado E; Department of Pharmaceutics, University of Washington.; Washington National Primate Research Center., Hensley-McBain T; Department of Pharmaceutics, University of Washington.; Washington National Primate Research Center., Miller C; Department of Pharmaceutics, University of Washington.; Washington National Primate Research Center., Cheu RK; Department of Pharmaceutics, University of Washington.; Washington National Primate Research Center., Collier AC; Department of Medicine, Harborview Medical Center, University of Washington, Seattle., Funderburg NT; School of Health and Rehabilitation Sciences, Division of Medical Laboratory Science, College of Medicine, Ohio State University, Columbus., Martin JN; Department of Epidemiology and Biostatistics, University of California, San Francisco., Wu MC; Public Health Science Division, Fred Hutchinson Cancer Research Center, Seattle, Washington., Isoherranen N; Department of Pharmaceutics, University of Washington., Hunt PW; Department of Medicine, University of California, San Francisco., Klatt NR; Department of Pharmaceutics, University of Washington.; Washington National Primate Research Center.
Jazyk:	angličtina
Zdroj:	Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2018 Jun 01; Vol. 66 (12), pp. 1872-1882.
DOI:	10.1093/cid/cix1116
Abstrakt:	Background: Cannabis is a widely used drug in the United States, and the frequency of cannabis use in the human immunodeficiency virus (HIV)-infected population is disproportionately high. Previous human and macaque studies suggest that cannabis may have an impact on plasma viral load; however, the relationship between cannabis use and HIV-associated systemic inflammation and immune activation has not been well defined. Methods: The impact of cannabis use on peripheral immune cell frequency, activation, and function was assessed in 198 HIV-infected, antiretroviral-treated individuals by flow cytometry. Individuals were categorized into heavy, medium, or occasional cannabis users or noncannabis users based on the amount of the cannabis metabolite 11-nor-carboxy-tetrahydrocannabinol (THC-COOH) detected in plasma by mass spectrometry. Results: Heavy cannabis users had decreased frequencies of human leukocyte antigen (HLA)-DR+CD38+CD4+ and CD8+ T-cell frequencies, compared to frequencies of these cells in non-cannabis-using individuals. Heavy cannabis users had decreased frequencies of intermediate and nonclassical monocyte subsets, as well as decreased frequencies of interleukin 23- and tumor necrosis factor-α-producing antigen-presenting cells. Conclusions: While the clinical implications are unclear, our findings suggest that cannabis use is associated with a potentially beneficial reduction in systemic inflammation and immune activation in the context of antiretroviral-treated HIV infection.
Databáze:	MEDLINE
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