Density and location of CD3 + and CD8 + tumor-infiltrating lymphocytes correlate with prognosis of oral squamous cell carcinoma.

Autor: Zhou C; Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Jiangsu, China.; Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Jiangnan University, Jiangsu, China., Wu Y; Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Jiangsu, China., Jiang L; Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Jiangsu, China., Li Z; Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital, Nanjing Medical University, Jiangsu, China., Diao P; Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Jiangsu, China., Wang D; Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Jiangsu, China., Zhang W; Department of Oral Pathology, School of Stomatology, Nanjing Medical University, Jiangsu, China., Liu L; Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Jiangsu, China.; Department of Oral Pathology, School of Stomatology, Nanjing Medical University, Jiangsu, China., Wang Y; Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Jiangsu, China., Jiang H; Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital, Nanjing Medical University, Jiangsu, China., Cheng J; Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Jiangsu, China.; Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital, Nanjing Medical University, Jiangsu, China., Yang J; Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Jiangsu, China.; Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital, Nanjing Medical University, Jiangsu, China.
Jazyk: angličtina
Zdroj: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology [J Oral Pathol Med] 2018 Apr; Vol. 47 (4), pp. 359-367. Date of Electronic Publication: 2018 Mar 12.
DOI: 10.1111/jop.12698
Abstrakt: Background: Tumor-infiltrating lymphocytes (TILs) are regarded as adaptive immune response of the host to cancer cells and valuable prognostic factors. Here, we sought to characterize the densities and locations of CD3 + and CD8 + TILs in primary oral squamous cell carcinoma (OSCC) samples and assess their clinicopathological and prognostic significance.
Methods: A total number of 169 OSCC samples from 2 independent patient cohorts (Nanjing cohort, 93 cases; Wuxi cohort, 76 cases) were retrospectively collected. The numbers of CD3 + and CD8 + TILs at tumor center (CT) and invasive margin (IM) of OSCC were identified by immunohistochemistry and calculated. The optimal cutoff values for CD3 + and CD8 + TILs to stratify patients were determined by X-tile software in Nanjing cohort and further utilized in Wuxi cohort. The associations between CD3 + /CD8 + TILs and clinicopathological parameters or patient survival were assessed. The prognostic values of CD3 + / CD8 + TILs were evaluated by Cox regression analyses.
Results: CD3 + and CD8 + TILs were identified at both CT and IM and enriched at IM. High density of CD3 + TILs at IM (CD3 IM) was significantly associated with increased overall and disease-specific survival (P < .05). High density of CD8 + TILs at CT (CD8 CT) was significantly associated with increased overall but not disease-specific survival. Moreover, CD3 IM and CD8 CT were identified as independent prognostic factors for patient survival.
Conclusions: Our findings provide further evidence to support the prognostic values of CD3 + and CD8 + TILs for OSCC, suggesting that TIL subsets might be viable biomarkers and therapeutic targets with translational significance.
(© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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