IFN-γ orchestrates tumor elimination, tumor dormancy, tumor escape, and progression.

Autor: Aqbi HF; Department of Microbiology & Immunology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.; Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA., Wallace M; Department of Microbiology & Immunology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA., Sappal S; Department of Microbiology & Immunology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA., Payne KK; Translational Tumor Immunology Program, The Wistar Institute, Philadelphia, Pennsylvania, USA., Manjili MH; Department of Microbiology & Immunology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.; Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Jazyk: angličtina
Zdroj: Journal of leukocyte biology [J Leukoc Biol] 2018 Feb 22. Date of Electronic Publication: 2018 Feb 22.
DOI: 10.1002/JLB.5MIR0917-351R
Abstrakt: Tumor immunoediting consisting of three phases of elimination, equilibrium or dormancy, and escape has been supported by preclinical and clinical data. A comprehensive understanding of the molecular mechanisms by which antitumor immune responses regulate these three phases are important for developing highly tailored immunotherapeutics that can control cancer. To this end, IFN-γ produced by Th1 cells, cytotoxic T cells, NK cells, and NKT cells is a pleiotropic cytokine that is involved in all three phases of tumor immunoediting, as well as during inflammation-mediated tumorigenesis processes. This essay presents a review of literature and suggests that overcoming tumor escape is feasible by driving tumor cells into a state of quiescent but not indolent dormancy in order for IFN-γ-producing tumor-specific T cells to prevent tumor relapse.
(©2018 Society for Leukocyte Biology.)
Databáze: MEDLINE
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