Left ventricular chamber geometry in cardiomyopathies: insights from a computerized anatomical study.

Autor: Juliani PS; Heart Institute (InCor) do Hospital das Clínicas da Faculdade de Medicina, Serviço de Cirurgia Toracica, Universidade de São Paulo, Av. Doutor Enéas de Carvalho Aguiar, 44, 5° andar, bloco II, sala 7, 04503-000, São Paulo, SP, Brazil., Das-Neves-Pereira JC; Heart Institute (InCor) do Hospital das Clínicas da Faculdade de Medicina, Serviço de Cirurgia Toracica, Universidade de São Paulo, Av. Doutor Enéas de Carvalho Aguiar, 44, 5° andar, bloco II, sala 7, 04503-000, São Paulo, SP, Brazil., Monteiro R; Heart Institute (InCor) do Hospital das Clínicas da Faculdade de Medicina, Serviço de Cirurgia Toracica, Universidade de São Paulo, Av. Doutor Enéas de Carvalho Aguiar, 44, 5° andar, bloco II, sala 7, 04503-000, São Paulo, SP, Brazil., Correia AT; Heart Institute (InCor) do Hospital das Clínicas da Faculdade de Medicina, Serviço de Cirurgia Toracica, Universidade de São Paulo, Av. Doutor Enéas de Carvalho Aguiar, 44, 5° andar, bloco II, sala 7, 04503-000, São Paulo, SP, Brazil., Moreira LFP; Heart Institute (InCor) do Hospital das Clínicas da Faculdade de Medicina, Serviço de Cirurgia Toracica, Universidade de São Paulo, Av. Doutor Enéas de Carvalho Aguiar, 44, 5° andar, bloco II, sala 7, 04503-000, São Paulo, SP, Brazil., Jatene FB; Heart Institute (InCor) do Hospital das Clínicas da Faculdade de Medicina, Serviço de Cirurgia Toracica, Universidade de São Paulo, Av. Doutor Enéas de Carvalho Aguiar, 44, 5° andar, bloco II, sala 7, 04503-000, São Paulo, SP, Brazil.
Jazyk: angličtina
Zdroj: ESC heart failure [ESC Heart Fail] 2018 Jun; Vol. 5 (3), pp. 355-364. Date of Electronic Publication: 2018 Feb 21.
DOI: 10.1002/ehf2.12261
Abstrakt: Aims: Some authors have hypothesized that left ventricular chamber dilatation in ischaemic and idiopathic cardiomyopathies results in spherical transformation. Aiming to characterize how this transformation occurs, a study was performed by comparing normal and dilated specimens regarding sphericity and proportionality in left heart chambers. It is important to provide data for the development of therapeutic strategies in these diseases.
Methods and Results: An anatomical study was performed by comparing normal (n = 10), ischaemic (n = 15), and idiopathic (n = 18) dilated human cardiomyopathic specimens regarding left ventricular chambers and their segmental proportionality to normal hearts. It was performed by capturing and processing images with proper software in three different levels of left ventricular chamber (basal, equatorial, and apical). These obtained data were analysed based on sphericity and proportionality by two dedicated indexes. Spherical shape: Calculated segmental indexes showed that dilated specimens were not spherical because they were smaller than as expected for a spherical shape (all values were <70% of a perfect sphere). Proportionality: There was no difference between basal index perimeters among groups, but apical index was lower in dilated specimens than in normal hearts, and so dilatation was not proportional to normal hearts.
Conclusions: Left ventricular chambers of anatomical specimens with dilated cardiomyopathies did not display a spherical shape and were not proportional to normal hearts.
(© 2018 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology.)
Databáze: MEDLINE
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