Prognostic and diagnostic value of elevated serum concentration of procalcitonin in patients with suspected heart failure. A review and meta-analysis.

Autor: Aïssou L; a Department of Cardiology , Avicenne Hospital, Hopitaux Universitaires Paris-Seine-Saint-Denis, APHP, Paris XIII University , France., Sorbets E; a Department of Cardiology , Avicenne Hospital, Hopitaux Universitaires Paris-Seine-Saint-Denis, APHP, Paris XIII University , France., Lallmahomed E; a Department of Cardiology , Avicenne Hospital, Hopitaux Universitaires Paris-Seine-Saint-Denis, APHP, Paris XIII University , France., Goudot FX; a Department of Cardiology , Avicenne Hospital, Hopitaux Universitaires Paris-Seine-Saint-Denis, APHP, Paris XIII University , France., Pop N; a Department of Cardiology , Avicenne Hospital, Hopitaux Universitaires Paris-Seine-Saint-Denis, APHP, Paris XIII University , France., Es-Sebbani S; a Department of Cardiology , Avicenne Hospital, Hopitaux Universitaires Paris-Seine-Saint-Denis, APHP, Paris XIII University , France., Benouda L; a Department of Cardiology , Avicenne Hospital, Hopitaux Universitaires Paris-Seine-Saint-Denis, APHP, Paris XIII University , France., Nuel G; b Gregory Nuel Conseil Scientifique , Paris , France., Meune C; a Department of Cardiology , Avicenne Hospital, Hopitaux Universitaires Paris-Seine-Saint-Denis, APHP, Paris XIII University , France.; c Institut National de la Santé et de la Recherche Médicale UMR S-942 , Paris , France.
Jazyk: angličtina
Zdroj: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals [Biomarkers] 2018 Jul; Vol. 23 (5), pp. 407-413. Date of Electronic Publication: 2018 Mar 12.
DOI: 10.1080/1354750X.2018.1443511
Abstrakt: Purpose: The diagnostic and prognostic significance of procalcitonin remains uncertain in HF patients. We reviewed and performed a meta-analysis of studies that measured PCT in HF patients, with or without infection.
Materials and Methods: We identified seven studies (9514 patients, 5810 with diagnoses of HF) eligible for our analysis, out of 247 examined. We estimated the serum PCT concentrations in patients with and without HF and/or infection and examined the mortality rates of patients with versus without elevated serum PCT concentrations.
Results: The mean age of the study samples ranged between 58 and 81 years, the men proportion between 47% and 66%, the follow-up duration between 22 and 180 days. The median PCT concentration in patients with HF and concomitant infections tended to be higher (0.26 ng/l [0.06, 0.46]) than in patients with HF alone (0.10 ng/l [0.08, 0.12]; p = 0.059). The mortality of patients suffering from HF and whose serum PCT concentrations were elevated was significantly higher than that of patients suffering from HF whose PCT concentrations were normal at 30 (2.66 [1.74, 4.05]), 90 (2.12 [1.59, 2.83]) and 180 days (2.06 [1.13, 3.78]).
Conclusions: In patients with HF, an elevated serum PCT concentration predicted the short-term risk of death.
Databáze: MEDLINE
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