| Autor: |
de Sousa Filho IA; Instituto de Química, Universidade de Brasília-UnB, Campus Darcy Ribeiro, Asa Norte, Brasília, DF, CEP-70910-000, Brazil. idiofilho@gmail.com., Lobo TM; Instituto de Química, Universidade de Brasília-UnB, Campus Darcy Ribeiro, Asa Norte, Brasília, DF, CEP-70910-000, Brazil., Grisolia CK; Instituto de Ciências Biologia, Departamento de Genética e Morfologia, Universidade de Brasília-UnB, Campus Darcy Ribeiro, Asa Norte, Brasília, DF, CEP-70910-000, Brazil., Weber IT; Instituto de Química, Universidade de Brasília-UnB, Campus Darcy Ribeiro, Asa Norte, Brasília, DF, CEP-70910-000, Brazil., Osugi ME; Instituto de Química, Universidade de Brasília-UnB, Campus Darcy Ribeiro, Asa Norte, Brasília, DF, CEP-70910-000, Brazil.; Unesp, Instituto Nacional de Tecnologias Alternativas para Detecção, Avaliação Toxicológica e Remoção de Micropoluentes e Radioativos (INCT-DATREM), Instituto de Química, Caixa Postal 355, Araraquara, SP, 14800-900, Brazil. |
| Abstrakt: |
Etoposide is an antineoplastic agent used for treating lung cancer, testicular cancer, breast cancer, pediatric cancers, and lymphomas. It is a pollutant due to its mutagenic and carcinogenic potential. Disposal of waste from this drug is still insufficiently safe, and there is no appropriate waste treatment. Therefore, it is important to use advanced oxidative processes (AOPs) for the treatment and disposal of medicines like this. The use of strontium stannate (SrSnO 3 ) as a catalyst in heterogeneous photocatalysis reactions has emerged as an alternative for the removal of organic pollutants. In our study, SrSnO 3 was synthesized by the combustion method and characterized by X-ray diffraction (XRD), Raman, UV-Vis, and scanning electron microscopy (SEM) techniques, obtaining a surface area of 3.28 m 2 g -1 with cubic and well-organized crystallinity and a band gap of 4.06 eV. The experimental conditions optimized for degradation of an etoposide solution (0.4 mg L -1 ) were pH 5 and catalyst concentration of 1 g L -1 . The results showed that the degradation processes using SrSnO 3 combined with H 2 O 2 (0.338 mol L -1 ) obtained total organic carbon removal from the etoposide solution, 97.98% (± 4.03 × 10 -3 ), compared with TiO 2 , which obtained a mineralization rate of 72.41% (± 6.95 × 10-3). After photodegradation, the degraded solution showed no toxicity to zebrafish embryos through embryotoxicity test (OECD, 236), and no genotoxicity using comet assay and micronucleus test. |
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