Personal exposure to fine particles (PM 2.5 ) and respiratory inflammation of common residents in Hong Kong.

Autor: Fan Z; The Jockey Club School of Public Healthh and Primary Care, The Chinese University of Hong Kong, Hong Kong, China., Pun VC; Saw Swee Hock School of Public Health, National University of Singapore, Singapore., Chen XC; The Jockey Club School of Public Healthh and Primary Care, The Chinese University of Hong Kong, Hong Kong, China; Institute of Environment, energy and Sustainability, The Chinese University of Hong Kong, Hong Kong, China., Hong Q; School of Public Health, The University of Hong Kong, Hong Kong, China., Tian L; School of Public Health, The University of Hong Kong, Hong Kong, China., Ho SS; Key Laboratory of Aerosol Chemistry and Physics, SKLLQG, Institute of Earth Environment, Chinese Academy of Sciences, Xi'an 710075, China., Lee SC; Department of Civil and Environmental Engineering, The Hong Kong Polytechnic University, Hong Kong, China., Tse LA; The Jockey Club School of Public Healthh and Primary Care, The Chinese University of Hong Kong, Hong Kong, China., Ho KF; The Jockey Club School of Public Healthh and Primary Care, The Chinese University of Hong Kong, Hong Kong, China; Institute of Environment, energy and Sustainability, The Chinese University of Hong Kong, Hong Kong, China. Electronic address: kfho@cuhk.edu.hk.
Jazyk: angličtina
Zdroj: Environmental research [Environ Res] 2018 Jul; Vol. 164, pp. 24-31. Date of Electronic Publication: 2018 Feb 22.
DOI: 10.1016/j.envres.2018.02.009
Abstrakt: Background: Given the lack of research on the personal exposure to fine particles (PM 2.5 ) in Hong Kong, we examined the association between short-term personal exposure to PM 2.5 and their constituents and inflammation in exhaled breath in a sample of healthy adult residents.
Method: Forty-six participants underwent personal PM 2.5 monitoring for averagely 6 days to obtain 276 samples. Fractional exhaled nitric oxide (FeNO), a biomarker of inflammation in exhaled breath, was measured at the end of each 24-h personal monitoring. PM 2.5 chemical constituents, including organic carbon, elemental carbon, 16 polycyclic aromatic hydrocarbons (PAHs), and 6 phthalate esters, were speciated from the personal samples collected. A mixed-effects model was used to estimate the association of PM 2.5 and their constituents with FeNO. The comparison was also made with parallel analyses using ambient concentrations.
Results: Personal exposures to PM 2.5 (28.1 ± 23.3 μg/m 3 ) were higher than the ambient levels (13.3 ± 6.4 μg/m 3 ) monitored by stations. The composition profile and personal-to-ambient concentration ratio varied among subjects with different occupations. An interquartile range (IQR) change in personal exposure to PM 2.5 was positively associated with 12.8% increase in FeNO (95% confidence interval, CI: 5.5-20.7%), while nil association was found for ambient PM 2.5 . Among the constituents measured, only the carcinogenic PAHs were significantly associated with 12% increase in FeNO responses (95% CI, 0.0-25.6%).
Conclusion: In conclusion, our study provides the first understanding about personal exposure to PM 2.5 and possible sources in Hong Kong. The results also showed that personal exposure to PM 2.5 and c-PAHs were linked to increased FeNO levels among healthy adults.
(Copyright © 2018 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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