Maturation trajectories of cortical resting-state networks depend on the mediating frequency band.

Autor: Khan S; Department of Neurology, MGH, Harvard Medical School, Boston, USA; Department of Radiology, MGH, Harvard Medical School, Boston, USA; Athinoula A. Martinos Center for Biomedical Imaging, MGH/HST, Charlestown, USA; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, USA. Electronic address: sheraz@nmr.mgh.harvard.edu., Hashmi JA; Department of Neurology, MGH, Harvard Medical School, Boston, USA; Athinoula A. Martinos Center for Biomedical Imaging, MGH/HST, Charlestown, USA., Mamashli F; Department of Neurology, MGH, Harvard Medical School, Boston, USA; Athinoula A. Martinos Center for Biomedical Imaging, MGH/HST, Charlestown, USA., Michmizos K; Department of Neurology, MGH, Harvard Medical School, Boston, USA; Athinoula A. Martinos Center for Biomedical Imaging, MGH/HST, Charlestown, USA., Kitzbichler MG; Department of Neurology, MGH, Harvard Medical School, Boston, USA; Athinoula A. Martinos Center for Biomedical Imaging, MGH/HST, Charlestown, USA., Bharadwaj H; Department of Neurology, MGH, Harvard Medical School, Boston, USA; Athinoula A. Martinos Center for Biomedical Imaging, MGH/HST, Charlestown, USA., Bekhti Y; Department of Neurology, MGH, Harvard Medical School, Boston, USA; Athinoula A. Martinos Center for Biomedical Imaging, MGH/HST, Charlestown, USA., Ganesan S; Department of Neurology, MGH, Harvard Medical School, Boston, USA; Athinoula A. Martinos Center for Biomedical Imaging, MGH/HST, Charlestown, USA., Garel KA; Department of Neurology, MGH, Harvard Medical School, Boston, USA; Athinoula A. Martinos Center for Biomedical Imaging, MGH/HST, Charlestown, USA., Whitfield-Gabrieli S; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, USA., Gollub RL; Department of Psychiatry MGH, Harvard Medical School, Boston, USA; Athinoula A. Martinos Center for Biomedical Imaging, MGH/HST, Charlestown, USA., Kong J; Department of Psychiatry MGH, Harvard Medical School, Boston, USA; Athinoula A. Martinos Center for Biomedical Imaging, MGH/HST, Charlestown, USA., Vaina LM; Department of Neurology, MGH, Harvard Medical School, Boston, USA; Department of Biomedical Engineering, Boston University, Boston, USA., Rana KD; Department of Biomedical Engineering, Boston University, Boston, USA., Stufflebeam SM; Department of Radiology, MGH, Harvard Medical School, Boston, USA; Athinoula A. Martinos Center for Biomedical Imaging, MGH/HST, Charlestown, USA., Hämäläinen MS; Department of Radiology, MGH, Harvard Medical School, Boston, USA; Athinoula A. Martinos Center for Biomedical Imaging, MGH/HST, Charlestown, USA., Kenet T; Department of Neurology, MGH, Harvard Medical School, Boston, USA; Athinoula A. Martinos Center for Biomedical Imaging, MGH/HST, Charlestown, USA.
Jazyk: angličtina
Zdroj: NeuroImage [Neuroimage] 2018 Jul 01; Vol. 174, pp. 57-68. Date of Electronic Publication: 2018 Feb 17.
DOI: 10.1016/j.neuroimage.2018.02.018
Abstrakt: The functional significance of resting state networks and their abnormal manifestations in psychiatric disorders are firmly established, as is the importance of the cortical rhythms in mediating these networks. Resting state networks are known to undergo substantial reorganization from childhood to adulthood, but whether distinct cortical rhythms, which are generated by separable neural mechanisms and are often manifested abnormally in psychiatric conditions, mediate maturation differentially, remains unknown. Using magnetoencephalography (MEG) to map frequency band specific maturation of resting state networks from age 7 to 29 in 162 participants (31 independent), we found significant changes with age in networks mediated by the beta (13-30 Hz) and gamma (31-80 Hz) bands. More specifically, gamma band mediated networks followed an expected asymptotic trajectory, but beta band mediated networks followed a linear trajectory. Network integration increased with age in gamma band mediated networks, while local segregation increased with age in beta band mediated networks. Spatially, the hubs that changed in importance with age in the beta band mediated networks had relatively little overlap with those that showed the greatest changes in the gamma band mediated networks. These findings are relevant for our understanding of the neural mechanisms of cortical maturation, in both typical and atypical development.
(Copyright © 2018. Published by Elsevier Inc.)
Databáze: MEDLINE