Octodrine: New Questions and Challenges in Sport Supplements.

Autor: Catalani V; Research Centre for Topical Drug Delivery and Toxicology, University of Hertfordshire, Herts SP9 11FA, UK. v.catalani@herts.ac.uk.; Department of Pharmacy, Pharmacology and Clinical Science, University of Hertfordshire, Herts AL10 9AB UK. v.catalani@herts.ac.uk., Prilutskaya M; Semey State Medical University, Republican Scientific and Practical Center of Mental Health, Pavlodar 140002, Kazakhstan. R.chilcott@herts.ac.uk., Al-Imam A; Faculty of Medicine, University of Baghdad, Baghdad 10071, Iraq. mariyapril2407@gmail.com., Marrinan S; Parliamentary Office of Science and Technology, Houses of Parliament, London SW1A 0AA UK. tesla1452@gmail.com., Elgharably Y; Navy General Hospital, Cardiovascular department, Alexandria 21513, Egypt. marrinans@parliament.uk., Zloh M; Department of Pharmacy, Pharmacology and Clinical Science, University of Hertfordshire, Herts AL10 9AB UK. yasmine_elgharably@ymail.com., Martinotti G; Department of Neuroscience, Imaging and Clinical Sciences, 'G.d'Annunzio' University, Chieti 66100 Italy. m.zloh@herts.ac.uk., Chilcott R; Research Centre for Topical Drug Delivery and Toxicology, University of Hertfordshire, Herts SP9 11FA, UK. Giovanni.Martinotti@gmail.com.; Department of Pharmacy, Pharmacology and Clinical Science, University of Hertfordshire, Herts AL10 9AB UK. Giovanni.Martinotti@gmail.com., Corazza O; Department of Pharmacy, Pharmacology and Clinical Science, University of Hertfordshire, Herts AL10 9AB UK. o.corazza@herts.ac.uk.
Jazyk: angličtina
Zdroj: Brain sciences [Brain Sci] 2018 Feb 20; Vol. 8 (2). Date of Electronic Publication: 2018 Feb 20.
DOI: 10.3390/brainsci8020034
Abstrakt: Background : Octodrine is the trade name for Dimethylhexylamine (DMHA), a central nervous stimulant that increases the uptake of dopamine and noradrenaline. Originally developed as a nasal decongestant in the 1950's, it has recently been re-introduced on the market as a pre-workout and 'fat-burner' product but its use remains unregulated. Our work provides the first observational cross-sectional analytic study on Octodrine as a new drug trend and its associated harms after a gap spanning seven decades. Methods : A comprehensive multilingual assessment of literature, websites, drug fora and other online resources was carried out with no time restriction in English, German, Russian and Arabic. Keywords included Octodrine's synonyms and chemical isomers. Results : Only five relevant publications emerged from the literature search, with most of the available data on body building websites and fora. Since 2015, Octodrine has been advertised online as "the next big thing" and "the god of stimulants," with captivating marketing strategies directed at athletes and a wider cohort of users. Reported side-effects include hypertension, dyspnoea and hyperthermia. Conclusions : The uncontrolled use of Octodrine, its physiological and psychoactive effects raise serious health implications with possible impact on athletes and doping practices. This new phenomenon needs to be thoroughly studied and monitored.
Competing Interests: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the article.
Databáze: MEDLINE
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