Vitamin D levels in acne vulgaris patients treated with oral isotretinoin.

Autor: El-Hamd MA; Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Sohag University, Sohag, Egypt., El Taieb MA; Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Aswan University, Aswan, Egypt., Ibrahim HM; Department of Dermatology, Venereology and Andrology, Faculty of Medicine, South Valley University, Qina, Egypt., Aly SS; Department of Clinical Pathology, Faculty of Medicine, South Valley University, Qina, Egypt.
Jazyk: angličtina
Zdroj: Journal of cosmetic dermatology [J Cosmet Dermatol] 2019 Feb; Vol. 18 (1), pp. 16-20. Date of Electronic Publication: 2018 Feb 20.
DOI: 10.1111/jocd.12503
Abstrakt: Background/objectives: Acne vulgaris is a common inflammatory skin disease. Vitamin D deficiency plays a role in many inflammatory skin diseases. It may play a role in pathogenesis of acne vulgaris. This study aimed to assess serum levels of 25 hydroxy vitamin D in patients with acne vulgaris before and after treatment with isotretinoin and its relation with acne vulgaris severity.
Methods: Ninety patients with acne vulgaris and 60 age-sex matched healthy subject as controls have been recruited in this study. Patients were treated with 0.75 mg/kg/d isotretinoin for 3 months. Serum level of 25 hydroxy vitamin D has been measured at baseline and after treatment.
Results: Serum levels of 25 hydroxy vitamin D were significantly higher in patients with acne vulgaris than healthy controls (P = .001). There was a significant inverse relation between level of 25 hydroxy vitamin D and severity of acne vulgaris before treatment (P = .001). Serum levels of 25 hydroxy vitamin D were significantly increased after isotretinoin treatment in patients with acne vulgaris (P = .001).
Conclusion: This study concluded that vitamin D may play a potential role in pathogenesis of acne vulgaris or acne vulgaris may have a negative effect on vitamin D synthesis. Further studies are needed to confirm these potential relations.
(© 2018 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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