Galectin-9 Is Critical for Mucosal Adaptive Immunity through the T Helper 17-IgA Axis.

Autor:	Liang CC; Ph.D. Program in Translational Medicine, China Medical University and Academia Sinica, Taichung, Taiwan; Department of Medicine, College of Medicine, China Medical University, Taichung, Taiwan; Division of Nephrology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Li CS; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Weng IC; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Chen HY; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Lu HH; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Huang CC; Ph.D. Program in Translational Medicine, China Medical University and Academia Sinica, Taichung, Taiwan; Department of Medicine, College of Medicine, China Medical University, Taichung, Taiwan; Division of Nephrology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan., Liu FT; Ph.D. Program in Translational Medicine, China Medical University and Academia Sinica, Taichung, Taiwan; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan; Department of Dermatology, School of Medicine, University of California-Davis, Sacramento, California. Electronic address: fliu@ucdavis.edu.
Jazyk:	angličtina
Zdroj:	The American journal of pathology [Am J Pathol] 2018 May; Vol. 188 (5), pp. 1225-1235. Date of Electronic Publication: 2018 Feb 17.
DOI:	10.1016/j.ajpath.2018.01.017
Abstrakt:	Impairment of the intestinal mucosal immunity significantly increases the risk of acute and chronic diseases. IgA plays a major role in humoral mucosal immunity to provide protection against pathogens and toxins in the gut. Here, we investigated the role of endogenous galectin-9, a tandem repeat-type β-galactoside-binding protein, in intestinal mucosal immunity. By mucosal immunization of Lgals9 -/- and littermate control mice, it was found that lack of galectin-9 impaired mucosal antigen-specific IgA response in the gut. Moreover, Lgals9 -/- mice were more susceptible to developing watery diarrhea and more prone to death in response to high-dose cholera toxin. The results indicate the importance of galectin-9 in modulating intestinal adaptive immunity. Furthermore, bone marrow chimera mice were established, and galectin-9 in hematopoietic cells was found to be critical for adaptive IgA response. In addition, immunized Lgals9 -/- mice exhibited lower expression of Il17 and fewer T helper 17 (Th17) cells in the lamina propria, implying that the Th17-IgA axis is involved in this mechanism. Taken together, these findings suggest that galectin-9 plays a role in mucosal adaptive immunity through the Th17-IgA axis. By manipulating the expression or activity of galectin-9, intestinal mucosal immune response can be altered and may benefit the development of mucosal vaccination. (Copyright © 2018 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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