The lymphoid cell network in the skin.

Autor: Tikoo S; The Centenary Institute, Newtown, NSW, 2042, Australia.; Discipline of Dermatology, Sydney Medical School, NSW, 2006, Australia., Jain R; The Centenary Institute, Newtown, NSW, 2042, Australia.; Discipline of Dermatology, Sydney Medical School, NSW, 2006, Australia., Kurz AR; The Centenary Institute, Newtown, NSW, 2042, Australia., Weninger W; The Centenary Institute, Newtown, NSW, 2042, Australia.; Discipline of Dermatology, Sydney Medical School, NSW, 2006, Australia.; Department of Dermatology, Royal Prince Alfred Hospital, Camperdown, NSW, 2050, Australia.
Jazyk: angličtina
Zdroj: Immunology and cell biology [Immunol Cell Biol] 2018 May; Vol. 96 (5), pp. 485-496. Date of Electronic Publication: 2018 Mar 23.
DOI: 10.1111/imcb.12026
Abstrakt: Cutaneous immunity represents a crucial component of the mammalian immune response. The presence of a large array of commensal microorganisms along with a myriad of environmental stresses necessitates constant immuno-surveillance of the tissue. To achieve a perfect balance between immune-tolerance and immune-activation, the skin harbors strategically localized immune cell populations that modulate these responses. To maintain homeostasis, innate and adaptive immune cells assimilate microenvironmental cues and coordinate cellular and molecular functions in a spatiotemporal manner. The role of lymphoid cells in cutaneous immunity is gaining much appreciation due to their important roles in regulating skin health and pathology. In this review, we aim to highlight the recent advances in the field of cutaneous lymphoid biology.
(© 2018 Australasian Society for Immunology Inc.)
Databáze: MEDLINE
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