The Risk of Traumatic Brain Injury Occurring Among Patients with Parkinson Disease: A 14-Year Population-Based Study.

Autor: Eric Nyam TT; Department of Neurosurgery, Chi Mei Medical Center, Tainan, Taiwan., Ho CH; Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan; Department of Hospital and Health Care Administration, Chia Nan University of Pharmacy and Science, Tainan, Taiwan., Wang YL; Department of Rehabilitation, Chi Mei Medical Center, Tainan, Taiwan., Lim SW; Department of Neurosurgery, Chi Mei Medical Center, Chiali, Tainan, Taiwan; Department of Nursing, Min-Hwei College of Health Care Management, Tainan, Taiwan., Wang JJ; Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan., Chio CC; Department of Neurosurgery, Chi Mei Medical Center, Tainan, Taiwan., Kuo JR; Department of Neurosurgery, Chi Mei Medical Center, Tainan, Taiwan; Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan; Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan, Taiwan. Electronic address: kuojinnrung@gmail.com., Wang CC; Department of Neurosurgery, Chi Mei Medical Center, Tainan, Taiwan; Center for General Education, Southern Taiwan University of Science and Technology, Tainan, Taiwan. Electronic address: wangchechuan@gmail.com.
Jazyk: angličtina
Zdroj: World neurosurgery [World Neurosurg] 2018 May; Vol. 113, pp. e328-e335. Date of Electronic Publication: 2018 Feb 13.
DOI: 10.1016/j.wneu.2018.02.027
Abstrakt: Background: Previous studies have implicated traumatic brain injury (TBI) as a risk factor for Parkinson disease (PD). However, the incidence risk of new-onset TBI among patients with PD is not well established. This study investigated the contribution of PD to new-onset TBI associations.
Methods: The study selected 6076 patients with PD and using 1:2 propensity score matching 12,152 general population cohorts in a longitudinal population database in Taiwan. The Cox proportional hazard regression model was used to estimate the hazard ratio of TBI adjusted with the potential confounding factors.
Results: The incidence of TBI in patients with PD (2.57%) and compared cohorts (1.81%) was significantly different (P = 0.0007). Patients with PD had a higher risk of TBI (hazard ratio, 1.63; 95% confidence interval, 1.32-2.01) compared with the general population. Patients with PD with TBI incidence had a higher Charlson Comorbidity Index than did the general population with TBI (P < 0.0001). Fall is the major cause of TBI in patients with PD.
Conclusions: This study shows that patients with PD have a high risk of TBI, and the major cause of TBI in patients with PD is fall.
(Copyright © 2018 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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