| Autor: |
Dashtiyan AA; Department of Physical Education & Sport Sciences, University of Birjand, Avini Blvd, Birjand, South Khorasan Province, Iran., Sepehrimanesh M; Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Khalili St, Shiraz, Fars Province, Iran., Tanideh N; Stem Cell Technology Research Center, Shiraz University of Medical Sciences, Khalili St, Shiraz, Fars Province, Iran., Afzalpour ME; Department of Physical Education & Sport Sciences, University of Birjand, Avini Blvd, Birjand, South Khorasan Province, Iran. |
| Jazyk: |
angličtina |
| Zdroj: |
Biochimie open [Biochim Open] 2017 Apr 01; Vol. 4, pp. 112-118. Date of Electronic Publication: 2017 Apr 01 (Print Publication: 2017). |
| DOI: |
10.1016/j.biopen.2017.03.005 |
| Abstrakt: |
The aim of this study was to investigate the effect of endurance training with and without vitamin E on the expression of p53 and Phosphatase and tension homolog (PTEN) tumor suppressor genes of prostate glands in male rats. For this purpose, 50 Sprague-Dawley male rats were randomly assigned into 5 groups: (1) control group (CON, n = 10), (2) sham (S, n = 10), (3) endurance training (ET, n = 10), (4) endurance training + vitamin E (ET + VE, n = 10), (5) vitamin E (VE, n = 10). Endurance training protocol was implemented for 6 weeks, 6 days per week, in accordance with the overload principle. To measure expression changes of p53 and PTEN genes in rats' prostate, real-time PCR method was used and HPLC method was used to measure vitamin E in this tissue. After 6 weeks of taking vitamin E, its level in all groups, except for group VE (p < 0.000) did not significantly increase. After implementing training protocol, p53 expression reduced significantly in ET group (p < 0.026). Vitamin E supplementation along with endurance training did not cause any significant change either p53 or PTEN (respectively; p < 0.2, p < 0.11). Instead, vitamin E supplementation without endurance training caused significant increase in PTEN, but did not cause any significant changes in p53 (respectively; p < 0.016, p < 0.15). These results indicate that endurance training reduces p53 and PTEN tumor suppressing genes expression, and taking vitamin E supplement could increase expression of these genes in some extent. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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