pMEX01, a 70kb plasmid isolated from Escherichia coli that confers resistance to multiple β-lactam antibiotics.

Autor: Hernandez-Flores JL; Unidad Irapuato, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Departamento de Ingeniería Genética, Irapuato, Guanajuato, Mexico., Pérez JC; Universidad Autónoma de Querétaro, Facultad de Química, Querétaro, Mexico., Gutiérrez CS; Universidad Autónoma de Querétaro, Facultad de Ciencias Naturales, Querétaro, Mexico., Hernández AC; Universidad Autónoma de Querétaro, Facultad de Química, Querétaro, Mexico., Alonso GS; Universidad Autónoma de Querétaro, Facultad de Ciencias Naturales, Querétaro, Mexico., Hernández SP; Universidad Autónoma de Querétaro, Facultad de Química, Querétaro, Mexico., Gómez SR; Universidad Autónoma de Querétaro, Facultad de Química, Querétaro, Mexico., Fernández F; Universidad Nacional Autónoma de México, Centro de Física Aplicada y Tecnología Avanzada, Querétaro, Mexico., Loske AM; Universidad Nacional Autónoma de México, Centro de Física Aplicada y Tecnología Avanzada, Querétaro, Mexico. Electronic address: loske@fata.unam.mx., Guillén JC; Universidad Autónoma de Querétaro, Facultad de Química, Querétaro, Mexico. Electronic address: juan.campos@uaq.mx.
Jazyk: angličtina
Zdroj: Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] [Braz J Microbiol] 2018 Jul - Sep; Vol. 49 (3), pp. 569-574. Date of Electronic Publication: 2018 Feb 03.
DOI: 10.1016/j.bjm.2017.11.002
Abstrakt: Multidrug-resistant microorganisms are of great concern to public health. Genetic mobile elements, such as plasmids, are among the most relevant mechanisms by which bacteria achieve this resistance. We obtained an Escherichia coli strain CM6, isolated from cattle presenting severe diarrheic symptoms in the State of Querétaro, Mexico. It was found to contain a 70kb plasmid (pMEX01) with a high similarity to the pHK01-like plasmids that were previously identified and described in Hong Kong. Analysis of the pMEX01 sequence revealed the presence of a bla CTX-M-14 gene, which is responsible for conferring resistance to multiple β-lactam antibiotics. Several genes putatively involved in the conjugative transfer were also identified on the plasmid. The strain CM6 is of high epidemiological concern because it not only displays resistance to multiple β-lactam antibiotics but also to other kinds of antibiotics.
(Published by Elsevier Editora Ltda.)
Databáze: MEDLINE
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