Three new abietane-type diterpenoids from the leaves of Indonesian Plectranthus scutellarioides.

Autor: Ito T; Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan. Electronic address: itot@inm.u-toyama.ac.jp., Rakainsa SK; Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan., Nisa K; Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan; Research Unit for Natural Products Technology, Indonesian Institute of Sciences (LIPI), Jl. Jogja-Wonosari Km.31.5, Playen, Gunungkidul, Yogyakarta, Indonesia., Morita H; Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan. Electronic address: hmorita@inm.u-toyama.ac.jp.
Jazyk: angličtina
Zdroj: Fitoterapia [Fitoterapia] 2018 Jun; Vol. 127, pp. 146-150. Date of Electronic Publication: 2018 Feb 12.
DOI: 10.1016/j.fitote.2018.02.013
Abstrakt: Three new diterpenoids, spiroscutelones A-C (1-3), along with known diterpene 4, were isolated from the leaves of Plectranthus scutellarioides. Their structures were established based on extensive spectroscopic analyses, including MS and NMR spectroscopy. Spiroscutelone A (1) represents the first example of an abietane-type terpenoid skeleton with a cyclobutane moiety linking the B and C rings. Of compounds 1-4, spiroscutelone B (2) exhibited the most potent cytotoxicities against the three tested human cancer lines [breast (MCF-7), pancreatic (PSN-1), and cervical (HeLa)] with IC 50 values ranging from 17.9 μM to 29.8 μM and low cytotoxicity against a lung fibroblast (WI-38) normal cell line.
(Copyright © 2018. Published by Elsevier B.V.)
Databáze: MEDLINE
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