| Autor: |
Adamson NJ; Department of Chemistry, Duke University , Durham, North Carolina 27708, United States., Wilbur KCE; Department of Chemistry, Duke University , Durham, North Carolina 27708, United States., Malcolmson SJ; Department of Chemistry, Duke University , Durham, North Carolina 27708, United States. |
| Abstrakt: |
We report a highly enantioselective Pd-PHOX-catalyzed intermolecular hydroalkylation of acyclic 1,3-dienes. Meldrum's acid derivatives and other activated C-pronucleophiles, such as β-diketones and malononitriles, react with a variety of aryl- and alkyl-substituted dienes in ≤20 h at room temperature. The coupled products, obtained in up to 96% yield and 97.5:2.5 er, are easily transformed into useful chemical building blocks for downstream synthesis. |
