Bowman layer transplantation: 5-year results.

Autor: van Dijk K; Netherlands Institute for Innovative Ocular Surgery, Laan op Zuid 88, 3071 AA, Rotterdam, The Netherlands.; Melles Cornea Clinic Rotterdam, Rotterdam, The Netherlands., Parker JS; Netherlands Institute for Innovative Ocular Surgery, Laan op Zuid 88, 3071 AA, Rotterdam, The Netherlands.; Melles Cornea Clinic Rotterdam, Rotterdam, The Netherlands.; UAB Callahan Eye Hospital, Birmingham, AL, USA., Baydoun L; Netherlands Institute for Innovative Ocular Surgery, Laan op Zuid 88, 3071 AA, Rotterdam, The Netherlands.; Melles Cornea Clinic Rotterdam, Rotterdam, The Netherlands., Ilyas A; Netherlands Institute for Innovative Ocular Surgery, Laan op Zuid 88, 3071 AA, Rotterdam, The Netherlands.; Amnitrans EyeBank Rotterdam, Rotterdam, The Netherlands., Dapena I; Netherlands Institute for Innovative Ocular Surgery, Laan op Zuid 88, 3071 AA, Rotterdam, The Netherlands.; Melles Cornea Clinic Rotterdam, Rotterdam, The Netherlands., Groeneveld-van Beek EA; Netherlands Institute for Innovative Ocular Surgery, Laan op Zuid 88, 3071 AA, Rotterdam, The Netherlands.; Amnitrans EyeBank Rotterdam, Rotterdam, The Netherlands., Melles GRJ; Netherlands Institute for Innovative Ocular Surgery, Laan op Zuid 88, 3071 AA, Rotterdam, The Netherlands. research@niios.com.; Melles Cornea Clinic Rotterdam, Rotterdam, The Netherlands. research@niios.com.; Amnitrans EyeBank Rotterdam, Rotterdam, The Netherlands. research@niios.com.
Jazyk: angličtina
Zdroj: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie [Graefes Arch Clin Exp Ophthalmol] 2018 Jun; Vol. 256 (6), pp. 1151-1158. Date of Electronic Publication: 2018 Feb 14.
DOI: 10.1007/s00417-018-3927-7
Abstrakt: Purpose: The purpose of this study was to evaluate the 5-year clinical results of isolated Bowman layer (BL) transplantation in the treatment of advanced keratoconus.
Methods: In this prospective, single-center, interventional case series at a tertiary referral center, 20 eyes of 17 patients with advanced keratoconus underwent BL transplantation, i.e. an isolated Bowman layer graft was positioned into a manually dissected mid-stromal pocket. Scheimpflug-based corneal tomography measurements, best corrected spectacle and contact lens visual acuities (BSCVA and BCLVA), endothelial cell density, and complications were evaluated up to 5 years after surgery.
Results: Measured simulated and maximum keratometry (Kmean and Kmax) values were stable up to 5 years after surgery (P = .310 and P = .195 for 5 years compared to 1 month follow-up, respectively), following an initial decrease from pre- to 1 month postoperatively (P < .001 each). Mean LogMAR BSCVA remained stable (P > .99), after an initial improvement from pre- to 12 months postoperatively (P = .007). Mean BCLVA did not change from preoperative to 5 years postoperatively (P = .219). During all postoperative follow-ups, mean densitometry values were higher than preoperatively (P < .001). A corneal hydrops occurred in one eye at 4.5 years postoperatively; no other postoperative complications were observed. Kaplan-Meier analysis showed an estimated success rate of 84% at 5 years postoperatively. Endothelial cell density remained stable from before to 5 years after surgery (P = .319).
Conclusions: After early postoperative corneal flattening, topographies were stable up to 5 years after BL transplantation, preserving BCLVA and contact lens tolerance, potentially allowing long term postponement of penetrating or deep anterior lamellar keratoplasty.
Databáze: MEDLINE
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