| Autor: |
Cardoso MA; Postgraduate Program Clinical Research in Infectious Diseases, National Institute of Infectious Diseases Evandro Chagas-Fiocruz, Manguinhos, RJ, Brazil., do Brasil PEAA; Clinical Research Laboratory on Immunizations and Surveillance, National Institute of Infectious Diseases Evandro Chagas-Fiocruz, Manguinhos, RJ, Brazil., Schmaltz CAS; Clinical Research Laboratory on Mycobacteria, National Institute of Infectious Diseases Evandro Chagas-Fiocruz, Manguinhos, RJ, Brazil., Sant'Anna FM; Clinical Research Laboratory on Mycobacteria, National Institute of Infectious Diseases Evandro Chagas-Fiocruz, Manguinhos, RJ, Brazil., Rolla VC; Clinical Research Laboratory on Mycobacteria, National Institute of Infectious Diseases Evandro Chagas-Fiocruz, Manguinhos, RJ, Brazil. |
| Jazyk: |
angličtina |
| Zdroj: |
BioMed research international [Biomed Res Int] 2017; Vol. 2017, pp. 3974651. Date of Electronic Publication: 2017 Dec 28. |
| DOI: |
10.1155/2017/3974651 |
| Abstrakt: |
Tuberculosis treatment has undergone recent changes in Brazil. Objective . To assess whether favorable outcomes on tuberculosis therapy improved in recent years. Methods . Retrospective observational study, based on primary data of tuberculosis patients, followed at INI-FIOCRUZ, from January 2012 to December 2014. Results . The outcomes observed were as follows: cure (80%), default (14%), treatment failure (5%), and death (1%). HIV infection without antiretroviral therapy [OR 0.34 (0.15-0.79)], tuberculosis diagnosis based on sputum smear [OR 0.22 (0.07-0.74)], drug use [OR 0.22 (0.11-0.46)], and/or treatment interruption due to adverse reactions [OR 0.23 (0.08-0.67)] decreased the chance of cure. Predictors of default, that is, use of noninjecting drugs [OR 3.00 (95% CL 1.31-6.88)], treatment interruption due to adverse reactions [OR 6.30 (1.81-21.95)], low schooling [OR 2.59 (2.15-5.82)], higher age [OR 0.44 (0.23-0.82)], and female gender [OR 0.28 (0.11-0.71)], reduced the chance of treatment default. Tuberculosis diagnosis based on sputum smear [OR 7.77 (1.94-31.09)] and/or arterial hypertension [OR 4.07 (1.25-13.18)] was associated with treatment failure. Conclusion . Mortality and default were low considering the prevalence of HIV infection; however cure was not significantly increased. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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