Common and divergent features of galactose-1-phosphate and fructose-1-phosphate toxicity in yeast.

Autor: Gibney PA; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544.; Calico Life Sciences LLC, South San Francisco, CA 94080.; Department of Food Science, Cornell University, Ithaca, NY 14853., Schieler A; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544., Chen JC; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544.; Department of Chemistry, Princeton University, Princeton, NJ 08544., Bacha-Hummel JM; Biology Department, Swarthmore College, Swarthmore, PA 19081., Botstein M; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544., Volpe M; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544., Silverman SJ; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544., Xu Y; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544.; Department of Chemistry, Princeton University, Princeton, NJ 08544., Bennett BD; Calico Life Sciences LLC, South San Francisco, CA 94080., Rabinowitz JD; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544.; Department of Chemistry, Princeton University, Princeton, NJ 08544., Botstein D; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544.; Calico Life Sciences LLC, South San Francisco, CA 94080.; Department of Food Science, Cornell University, Ithaca, NY 14853.
Jazyk: angličtina
Zdroj: Molecular biology of the cell [Mol Biol Cell] 2018 Apr 15; Vol. 29 (8), pp. 897-910. Date of Electronic Publication: 2018 Mar 30.
DOI: 10.1091/mbc.E17-11-0666
Abstrakt: Metabolic dysregulation leading to sugar-phosphate accumulation is toxic in organisms ranging from bacteria to humans. By comparing two models of sugar-phosphate toxicity in Saccharomyces cerevisiae, we demonstrate that toxicity occurs, at least in part, through multiple, isomer-specific mechanisms, rather than a single general mechanism.
Databáze: MEDLINE