Short-term early exposure to thirdhand cigarette smoke increases lung cancer incidence in mice.

Autor:	Hang B; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, U.S.A., Wang Y; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, U.S.A.; International Biotechnology R&D Center, Shandong University School of Ocean, Weihai, Shandong 264209, China., Huang Y; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, U.S.A., Wang P; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, U.S.A.; Department of Gastroenterology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu 210008, China., Langley SA; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, U.S.A., Bi L; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, U.S.A., Sarker AH; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, U.S.A., Schick SF; Department of Medicine, Division of Occupational and Environmental Medicine, University of California, San Francisco, Box 0843, San Francisco, CA 94143, U.S.A., Havel C; Division of Clinical Pharmacology and Experimental Therapeutics, Department of Medicine University of California, San Francisco, Box 0843, San Francisco, CA 94143, U.S.A., Jacob P 3rd; Division of Clinical Pharmacology and Experimental Therapeutics, Department of Medicine University of California, San Francisco, Box 0843, San Francisco, CA 94143, U.S.A., Benowitz N; Division of Clinical Pharmacology and Experimental Therapeutics, Medical Services, Department of Medicine, and Bioengineering & Therapeutic Sciences, University of California, San Francisco, Box 0843, San Francisco, CA 94143, U.S.A., Destaillats H; Indoor Environment Group, Energy Technologies Area, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, U.S.A., Tang X; Indoor Environment Group, Energy Technologies Area, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, U.S.A., Xia Y; State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing 211166, China., Jen KY; Department of Pathology and Laboratory Medicine, University of California Davis Medical Center, Sacramento, CA 95817, U.S.A., Gundel LA; Indoor Environment Group, Energy Technologies Area, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, U.S.A., Mao JH; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, U.S.A. JHMao@lbl.gov AMSnijders@lbl.gov.; Berkeley Biomedical Data Science Center, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, U.S.A., Snijders AM; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, U.S.A. JHMao@lbl.gov AMSnijders@lbl.gov.; Berkeley Biomedical Data Science Center, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, U.S.A.
Jazyk:	angličtina
Zdroj:	Clinical science (London, England : 1979) [Clin Sci (Lond)] 2018 Feb 28; Vol. 132 (4), pp. 475-488. Date of Electronic Publication: 2018 Feb 28 (Print Publication: 2018).
DOI:	10.1042/CS20171521
Abstrakt:	Exposure to thirdhand smoke (THS) is a recently described health concern that arises in many indoor environments. However, the carcinogenic potential of THS, a critical consideration in risk assessment, remains untested. Here we investigated the effects of short-term early exposure to THS on lung carcinogenesis in A/J mice. Forty weeks after THS exposure from 4 to 7 weeks of age, the mice had increased incidence of lung adenocarcinoma, tumor size and, multiplicity, compared with controls. In vitro studies using cultured human lung cancer cells showed that THS exposure induced DNA double-strand breaks and increased cell proliferation and colony formation. RNA sequencing analysis revealed that THS exposure induced endoplasmic reticulum stress and activated p53 signaling. Activation of the p53 pathway was confirmed by an increase in its targets p21 and BAX. These data indicate that early exposure to THS is associated with increased lung cancer risk. (© 2018 The Author(s).)
Databáze:	MEDLINE
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