Effect of tiotropium on spontaneous expiratory flow-volume curves during exercise in GOLD 1-2 COPD.

Autor: Porszasz J; Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA. Electronic address: porszasz@ucla.edu., Carraro N; Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA., Cao R; Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA. Electronic address: rcao@labiomed.org., Gore A; Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA., Ma S; Center for Infectious Disease Research, Seattle, WA, USA. Electronic address: shuyima1@illinois.edu., Jiang T; Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA., Maltais F; Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Québec, Canada. Electronic address: francois.maltais@med.ulaval.ca., Ferguson GT; Pulmonary Research Institute of Southeast Michigan, Farmington Hills, MI, USA. Electronic address: garytferguson@msn.com., O'Donnell DE; Department of Medicine, Queen's University & Kingston General Hospital, Kingston, ON, Canada. Electronic address: odonnell@queensu.ca., Shaikh A; Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, USA. Electronic address: asif.shaikh@boehringer-ingelheim.com., Rossiter HB; Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA; Faculty of Biological Sciences, University of Leeds, Leeds, UK. Electronic address: hrossiter@ucla.edu., Casaburi R; Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA. Electronic address: casaburi@ucla.edu.
Jazyk: angličtina
Zdroj: Respiratory physiology & neurobiology [Respir Physiol Neurobiol] 2018 May; Vol. 251, pp. 8-15. Date of Electronic Publication: 2018 Feb 10.
DOI: 10.1016/j.resp.2018.02.006
Abstrakt: This substudy of a large, randomized, controlled trial (NCT01072396) examined tiotropium (18 μg qd) effects on dynamic hyperinflation during constant work rate treadmill exercise. Areas-under-the-spontaneous expiratory flow-volume (SEFV)-curves were compared in 20 COPD patients and 16 age-matched untreated controls, using rectangular area ratio (RAR) between peak intrabreath and end-expiratory flow. Seven patients exhibited SEFV curve concavity with RAR ≤ 0.5 (RAR low ) in ≥1 test without tiotropium; (mean ± SD FEV 1 : 1.60 ± 0.59 L; 63.4 ± 14.0%predicted). In RAR low patients, tiotropium increased end-exercise inspiratory capacity (IC, 2.10 ± 0.05 vs. 1.89 ± 0.05 L, tiotropium vs. placebo; p = 0.045) and RAR (0.57 ± 0.02 vs. 0.53 ± 0.02; p < 0.001). Patients without SEFV curve concavity with RAR > 0.5 (n = 13; RAR high ), had higher screening FEV 1 (2.15 ± 0.47 L; 79.6 ± 10.1%predicted) versus RAR low patients and no difference in end-exercise IC and RAR between tiotropium and placebo (IC: 2.24 ± 0.03 vs. 2.17 ± 0.03 L; RAR: 0.63 ± 0.005 vs. 0.62 ± 0.005). RAR and%predicted IC at peak exercise were positively correlated in RAR low patients (R 2  = 0.43, p = 0.0002). Tiotropium increased exercise RAR in GOLD 1-2 patients with SEFV curve concavity.
(Copyright © 2018 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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