Effect of tiotropium on spontaneous expiratory flow-volume curves during exercise in GOLD 1-2 COPD.
Autor: | Porszasz J; Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA. Electronic address: porszasz@ucla.edu., Carraro N; Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA., Cao R; Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA. Electronic address: rcao@labiomed.org., Gore A; Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA., Ma S; Center for Infectious Disease Research, Seattle, WA, USA. Electronic address: shuyima1@illinois.edu., Jiang T; Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA., Maltais F; Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Québec, Canada. Electronic address: francois.maltais@med.ulaval.ca., Ferguson GT; Pulmonary Research Institute of Southeast Michigan, Farmington Hills, MI, USA. Electronic address: garytferguson@msn.com., O'Donnell DE; Department of Medicine, Queen's University & Kingston General Hospital, Kingston, ON, Canada. Electronic address: odonnell@queensu.ca., Shaikh A; Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, USA. Electronic address: asif.shaikh@boehringer-ingelheim.com., Rossiter HB; Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA; Faculty of Biological Sciences, University of Leeds, Leeds, UK. Electronic address: hrossiter@ucla.edu., Casaburi R; Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA. Electronic address: casaburi@ucla.edu. |
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Jazyk: | angličtina |
Zdroj: | Respiratory physiology & neurobiology [Respir Physiol Neurobiol] 2018 May; Vol. 251, pp. 8-15. Date of Electronic Publication: 2018 Feb 10. |
DOI: | 10.1016/j.resp.2018.02.006 |
Abstrakt: | This substudy of a large, randomized, controlled trial (NCT01072396) examined tiotropium (18 μg qd) effects on dynamic hyperinflation during constant work rate treadmill exercise. Areas-under-the-spontaneous expiratory flow-volume (SEFV)-curves were compared in 20 COPD patients and 16 age-matched untreated controls, using rectangular area ratio (RAR) between peak intrabreath and end-expiratory flow. Seven patients exhibited SEFV curve concavity with RAR ≤ 0.5 (RAR (Copyright © 2018 Elsevier B.V. All rights reserved.) |
Databáze: | MEDLINE |
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