Genotoxicity of Turnera subulata and Spondias mombin × Spondias tuberosa Extracts from Brazilian Caatinga Biome.

Autor:	Senes-Lopes TF; 1 Program of Postgraduation in Health Sciences, Federal University of Rio Grande do Norte (UFRN) , Natal, Rio Grande do Norte, Brazil ., López JA; 2 Program of Postgraduation in Industrial Biotechnology, Institute of Technology and Research/Tiradentes University (UNIT) , Aracaju, Sergipe, Brazil ., do Amaral VS; 3 Department of Cell Biology and Genetics, Biosciences Center, Federal University of Rio Grande do Norte (UFRN) , Natal, Rio Grande do Norte, Brazil ., Brandão-Neto J; 1 Program of Postgraduation in Health Sciences, Federal University of Rio Grande do Norte (UFRN) , Natal, Rio Grande do Norte, Brazil .; 2 Program of Postgraduation in Industrial Biotechnology, Institute of Technology and Research/Tiradentes University (UNIT) , Aracaju, Sergipe, Brazil .; 3 Department of Cell Biology and Genetics, Biosciences Center, Federal University of Rio Grande do Norte (UFRN) , Natal, Rio Grande do Norte, Brazil .; 4 Department of Internal Medicine, Federal University of Rio Grande do Norte (UFRN) , Natal, Rio Grande do Norte, Brazil ., de Rezende AA; 1 Program of Postgraduation in Health Sciences, Federal University of Rio Grande do Norte (UFRN) , Natal, Rio Grande do Norte, Brazil .; 2 Program of Postgraduation in Industrial Biotechnology, Institute of Technology and Research/Tiradentes University (UNIT) , Aracaju, Sergipe, Brazil .; 3 Department of Cell Biology and Genetics, Biosciences Center, Federal University of Rio Grande do Norte (UFRN) , Natal, Rio Grande do Norte, Brazil .; 4 Department of Internal Medicine, Federal University of Rio Grande do Norte (UFRN) , Natal, Rio Grande do Norte, Brazil .; 5 Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte (UFRN) , Natal, Rio Grande do Norte, Brazil ., da Luz JRD; 1 Program of Postgraduation in Health Sciences, Federal University of Rio Grande do Norte (UFRN) , Natal, Rio Grande do Norte, Brazil ., Guterres ZDR; 6 Laboratory of Cytogenetics and Mutagenesis, State University of Mato Grosso do Sul (UEMS) , Mundo Novo, Matto Grasso do Sul, Brazil ., Almeida MDG; 1 Program of Postgraduation in Health Sciences, Federal University of Rio Grande do Norte (UFRN) , Natal, Rio Grande do Norte, Brazil .; 2 Program of Postgraduation in Industrial Biotechnology, Institute of Technology and Research/Tiradentes University (UNIT) , Aracaju, Sergipe, Brazil .; 3 Department of Cell Biology and Genetics, Biosciences Center, Federal University of Rio Grande do Norte (UFRN) , Natal, Rio Grande do Norte, Brazil .; 4 Department of Internal Medicine, Federal University of Rio Grande do Norte (UFRN) , Natal, Rio Grande do Norte, Brazil .; 5 Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte (UFRN) , Natal, Rio Grande do Norte, Brazil .
Jazyk:	angličtina
Zdroj:	Journal of medicinal food [J Med Food] 2018 Apr; Vol. 21 (4), pp. 372-379. Date of Electronic Publication: 2018 Feb 13.
DOI:	10.1089/jmf.2017.0041
Abstrakt:	Medicinal plants have been used in primary healthcare since the earliest days of humankind. Turnera subulata and Spondias mombin × Spondias tuberosa are widely used in the Brazilian Northeast to treat several diseases. The aim of this study was to evaluate the genotoxic effects of the leaf extracts of these species by the somatic mutation and recombination test in the somatic cells of Drosophila melanogaster wings. The experiments were performed using standard and high-bioactivation cross and three concentrations of the test substance [aqueous extract (AET and AES) at 5.0, 10.0, and 20.0 mg/mL and ethanolic extract (EET and EES) and ethyl acetate fraction (EAFT and EAFS) at 0.625, 1.25, and 2.5 mg/mL]. Results indicated that the extracts and fractions induced spontaneous frequencies of mutant spots in both D. melanogaster crosses. Nevertheless, the highest concentrations of the tested plant chemical agents were responsible for the statistically significant genotypic effect. T. subulata and S. mombin × S. tuberosa displayed genotoxic effect under the experimental conditions. The results from this study are crucial as they indicated the deleterious and side effects, considering the indiscriminate use of the extracts of these plants for disease treatment.
Databáze:	MEDLINE
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