Atherogenic index of plasma and 10-year risk of cardiovascular disease in adult Africans living with HIV infection: A cross-sectional study from Yaoundé, Cameroon.

Autor: Noumegni SR; 1Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon.; Faculty of Medicine, University of Paris Sud XI, Le Kremlin Bicêtre, France., Nansseu JR; Department of Public Health, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon., Bigna JJ; Faculty of Medicine, University of Paris Sud XI, Le Kremlin Bicêtre, France.; Department of Epidemiology and Public Health, Centre Pasteur of Cameroon, Yaoundé, Cameroon., Ama Moor VJ; Department of Biochemistry and Physiological Sciences, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon.; Laboratory of Biochemistry, University Teaching Hospital, Yaoundé, Cameroon., Kembe Assah F; Department of Public Health, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon., Dehayem MY; National Obesity Center, Yaoundé Central Hospital, Yaoundé, Cameroon., Kengne AP; Non-Communicable Diseases Research Unit, South African Medical Research Council, Cape Town, South Africa.; 9Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa., Sobngwi E; National Obesity Center, Yaoundé Central Hospital, Yaoundé, Cameroon.; Laboratory of Molecular Medicine and Metabolism, Biotechnology Center, University of Yaoundé 1, Yaoundé, Cameroon.; Departement of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon.
Jazyk: angličtina
Zdroj: JRSM cardiovascular disease [JRSM Cardiovasc Dis] 2017 Nov 06; Vol. 6, pp. 2048004017740478. Date of Electronic Publication: 2017 Nov 06 (Print Publication: 2017).
DOI: 10.1177/2048004017740478
Abstrakt: Background: The paucity of data regarding the association between atherogenic index of plasma and risk of cardiovascular disease in HIV-infected populations living in sub-Saharan Africa prompted us to conduct this study which aimed to assess the relationship between atherogenic index of plasma and risk of cardiovascular disease among a Cameroonian HIV-infected population.
Methods: This was a cross-sectional study conducted among 452 HIV-infected adults in Yaoundé, Cameroon. Risk of cardiovascular disease was calculated using the Framingham risk score; atherogenic index of plasma was derived as log (triglycerides/high-density lipoproteins cholesterol).
Results: Participants' mean age (80% females) was 44.4 ± 9.8 years. Atherogenic index of plasma values ranged from -0.63 to 1.36 with a median of 0.11 (25th-75th percentiles: -0.08-0.31). Most participants (88.5%) were on antiretroviral treatment. There was a significant correlation between atherogenic index of plasma and fasting plasma glucose (r = 0.116; p  = 0.014), atherogenic index of plasma and total cholesterol (r = -0.164; p  < 0.001). Atherogenic index of plasma was significantly associated with the risk of cardiovascular disease either in univariable (β = 5.05, 95% CI: 3.31-6.79; p  < 0.001, R 2  = 0.067) or in multivariable linear regression model after adjusting for socio-demographic, clinical and biological confounders (adjusted β = 3.79, 95% CI: 1.65 - 4.88; p  < 0.001, R 2  = 0.187).
Conclusion: Atherogenic index of plasma may be an independent factor impacting the risk of cardiovascular disease among Cameroonian HIV-infected people. More studies are needed to better elucidate the association between atherogenic index of plasma and risk of cardiovascular disease in our setting.
Databáze: MEDLINE
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