Clonal polymorphism and high heterozygosity in the celibate genome of the Amazon molly.

Autor: Warren WC; McDonnell Genome Institute, School of Medicine, Washington University, St Louis, MO, USA. wwarren@genome.wustl.edu., García-Pérez R; Institute of Evolutionary Biology (UPF-CSIC), PRBB, Barcelona, Spain., Xu S; Department of Biology, University of Texas at Arlington, Arlington, TX, USA., Lampert KP; Department of Animal Ecology, Evolution and Biodiversity, Ruhr-Universität Bochum, Bochum, Germany., Chalopin D; Institut de Génomique Fonctionnelle de Lyon, Ecole Normale Supérieure de Lyon, CNRS, Université Lyon, Lyon, France., Stöck M; Leibniz-Institute of Freshwater Ecology and Inland Fisheries, Berlin, Germany., Loewe L; Laboratory of Genetics and Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, USA., Lu Y; Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX, USA., Kuderna L; Institute of Evolutionary Biology (UPF-CSIC), PRBB, Barcelona, Spain., Minx P; McDonnell Genome Institute, School of Medicine, Washington University, St Louis, MO, USA., Montague MJ; Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Tomlinson C; McDonnell Genome Institute, School of Medicine, Washington University, St Louis, MO, USA., Hillier LW; McDonnell Genome Institute, School of Medicine, Washington University, St Louis, MO, USA., Murphy DN; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK., Wang J; Biodiversity Research Center, Academica Sinica Taipei, Taipei, Taiwan., Wang Z; Department of Physiological Chemistry, Biocenter, University of Würzburg, Würzburg, Germany.; Institute of Hydrobiology, Chinese Academy of Sciences, Beijing, China., Garcia CM; Instituto de Ecología, Universidad Nacional Autónoma de México, Ciudad Universitaria, Mexico City, Mexico., Thomas GCW; Department of Biology, Indiana University, Bloomington, IN, USA., Volff JN; Institut de Génomique Fonctionnelle de Lyon, Ecole Normale Supérieure de Lyon, CNRS, Université Lyon, Lyon, France., Farias F; McDonnell Genome Institute, School of Medicine, Washington University, St Louis, MO, USA., Aken B; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK., Walter RB; Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX, USA., Pruitt KD; National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA., Marques-Bonet T; Institute of Evolutionary Biology (UPF-CSIC), PRBB, Barcelona, Spain.; Center for Genomic Regulation (CGR), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.; Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain., Hahn MW; Department of Biology, Indiana University, Bloomington, IN, USA., Kneitz S; Department of Physiological Chemistry, Biocenter, University of Würzburg, Würzburg, Germany., Lynch M; Department of Biology, Indiana University, Bloomington, IN, USA., Schartl M; Department of Physiological Chemistry, Biocenter, University of Würzburg, Würzburg, Germany.; Hagler Institute for Advanced Study and Department of Biology, Texas A&M University, College Station, TX, USA.; Comprehensive Cancer Center Mainfranken, University Hospital Würzburg, Würzburg, Germany.
Jazyk: angličtina
Zdroj: Nature ecology & evolution [Nat Ecol Evol] 2018 Apr; Vol. 2 (4), pp. 669-679. Date of Electronic Publication: 2018 Feb 12.
DOI: 10.1038/s41559-018-0473-y
Abstrakt: The extreme rarity of asexual vertebrates in nature is generally explained by genomic decay due to absence of meiotic recombination, thus leading to extinction of such lineages. We explore features of a vertebrate asexual genome, the Amazon molly, Poecilia formosa, and find few signs of genetic degeneration but unique genetic variability and ongoing evolution. We uncovered a substantial clonal polymorphism and, as a conserved feature from its interspecific hybrid origin, a 10-fold higher heterozygosity than in the sexual parental species. These characteristics seem to be a principal reason for the unpredicted fitness of this asexual vertebrate. Our data suggest that asexual vertebrate lineages are scarce not because they are at a disadvantage, but because the genomic combinations required to bypass meiosis and to make up a functioning hybrid genome are rarely met in nature.
Databáze: MEDLINE