Characteristics of systemic lupus erythematosus in a sample of the Egyptian population: a retrospective cohort of 1109 patients from a single center.

Autor:	El Hadidi KT; 1 Rheumatology and Rehabilitation Department, 63527 Kasr Al Ainy Faculty of Medicine, Cairo University , Cairo, Egypt., Medhat BM; 1 Rheumatology and Rehabilitation Department, 63527 Kasr Al Ainy Faculty of Medicine, Cairo University , Cairo, Egypt., Abdel Baki NM; 1 Rheumatology and Rehabilitation Department, 63527 Kasr Al Ainy Faculty of Medicine, Cairo University , Cairo, Egypt., Abdel Kafy H; 2 Rheumatology Department, 68821 Al Azhar University Faculty of Medicine , Cairo, Egypt., Abdelrahaman W; 1 Rheumatology and Rehabilitation Department, 63527 Kasr Al Ainy Faculty of Medicine, Cairo University , Cairo, Egypt., Yousri AY; 1 Rheumatology and Rehabilitation Department, 63527 Kasr Al Ainy Faculty of Medicine, Cairo University , Cairo, Egypt., Attia DH; 1 Rheumatology and Rehabilitation Department, 63527 Kasr Al Ainy Faculty of Medicine, Cairo University , Cairo, Egypt., Eissa M; 1 Rheumatology and Rehabilitation Department, 63527 Kasr Al Ainy Faculty of Medicine, Cairo University , Cairo, Egypt., El Dessouki D; 3 Rheumatology Department, National Research Centre, Cairo, Egypt., Elgazzar I; 1 Rheumatology and Rehabilitation Department, 63527 Kasr Al Ainy Faculty of Medicine, Cairo University , Cairo, Egypt., Elgengehy FT; 1 Rheumatology and Rehabilitation Department, 63527 Kasr Al Ainy Faculty of Medicine, Cairo University , Cairo, Egypt., El Ghobashy N; 1 Rheumatology and Rehabilitation Department, 63527 Kasr Al Ainy Faculty of Medicine, Cairo University , Cairo, Egypt., El Hadary H; 1 Rheumatology and Rehabilitation Department, 63527 Kasr Al Ainy Faculty of Medicine, Cairo University , Cairo, Egypt., El Mardenly G; 1 Rheumatology and Rehabilitation Department, 63527 Kasr Al Ainy Faculty of Medicine, Cairo University , Cairo, Egypt., El Naggar H; 4 Ministry of Health, Cairo, Egypt., El Nahas AM; 4 Ministry of Health, Cairo, Egypt., El Refai RM; 1 Rheumatology and Rehabilitation Department, 63527 Kasr Al Ainy Faculty of Medicine, Cairo University , Cairo, Egypt., El Rwiny HA; 4 Ministry of Health, Cairo, Egypt., Elsman RM; 5 Rheumatology Department, Helwan University, Cairo, Egypt., Galal M; 4 Ministry of Health, Cairo, Egypt., Ghoniem S; 1 Rheumatology and Rehabilitation Department, 63527 Kasr Al Ainy Faculty of Medicine, Cairo University , Cairo, Egypt., Maged LA; 1 Rheumatology and Rehabilitation Department, 63527 Kasr Al Ainy Faculty of Medicine, Cairo University , Cairo, Egypt., Sally SM; 1 Rheumatology and Rehabilitation Department, 63527 Kasr Al Ainy Faculty of Medicine, Cairo University , Cairo, Egypt., Naji H; 6 Rheumatology and Rehabilitation Department, Military Academy, Agouza Rheumatology and Rehabilitation Centre, Giza, Egypt., Saad S; 4 Ministry of Health, Cairo, Egypt., Shaaban M; 5 Rheumatology Department, Helwan University, Cairo, Egypt., Sharaf M; 4 Ministry of Health, Cairo, Egypt., Sobhy N; 1 Rheumatology and Rehabilitation Department, 63527 Kasr Al Ainy Faculty of Medicine, Cairo University , Cairo, Egypt., Soliman RM; 4 Ministry of Health, Cairo, Egypt., El Hadidi TS; 6 Rheumatology and Rehabilitation Department, Military Academy, Agouza Rheumatology and Rehabilitation Centre, Giza, Egypt.
Jazyk:	angličtina
Zdroj:	Lupus [Lupus] 2018 May; Vol. 27 (6), pp. 1030-1038. Date of Electronic Publication: 2018 Feb 10.
DOI:	10.1177/0961203317751856
Abstrakt:	Introduction Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease that can vary among different ethnic and racial groups. Objective The objective of this paper is to study the prevalence of various manifestations of SLE in a sample of the Egyptian population. Patients and methods Information in this study was derived from the medical records of SLE patients who sought medical advice at a private clinic in Cairo from January 1980 to June 2016. Results This study included 1109 SLE patients, of whom 114 (10.3%) were males and 995 were females (89.7%). Mean age of onset was 25.89 ± 10.81 years, while the median of disease duration from the onset of the disease till the last recorded visit was 26 months. The most common cumulative manifestations were arthritis (76.7%), malar rash (48.5%), leukopenia (45.7%), and photosensitivity (45.6%). A total of 33.1% of the patients had nephritis, and neuropsychiatric lupus was present in 6.4% of the patients. Secondary antiphospholipid syndrome was present in 11.5% of the patients. Antinuclear antibody and anti-double-stranded deoxyribonucleic acid were present in 1060/1094 (96.9%) and 842/1062 (79.3%) of the patients, respectively. Antiphospholipid antibodies were present in 266/636 (41.8%) of the patients, anti-Smith in 54/240 (22.5%), anti-SSA/Ro in 61/229 (20.4%), and anti-SSB/La in 32/277 (11.6%) of the patients. Male patients had a statistically higher prevalence of nephritis ( p = 0.01), whereas arthritis and alopecia were statistically higher in females ( p = 0.012 and p = 0.006, respectively). Patients with juvenile onset had a statistically higher prevalence of nephritis and seizures ( p < 0.001 and p = 0.012, respectively). Conclusions Arthritis and malar rash represented the most common clinical manifestations. Male and juvenile-onset patients had a predilection toward a more severe disease. These results are in agreement with many studies conducted in the Middle East and worldwide. On the other hand, major organ involvement was exceptionally low, which is contradictory to several reports from the Middle East and across the globe.
Databáze:	MEDLINE
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