Complex segregation analysis of craniomandibular osteopathy in Deutsch Drahthaar dogs.

Autor: Vagt J; Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover (Foundation), Bünteweg 17p, 30559 Hannover, Germany., Distl O; Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover (Foundation), Bünteweg 17p, 30559 Hannover, Germany. Electronic address: ottmar.distl@tiho-hannover.de.
Jazyk: angličtina
Zdroj: Veterinary journal (London, England : 1997) [Vet J] 2018 Jan; Vol. 231, pp. 30-32. Date of Electronic Publication: 2017 Nov 22.
DOI: 10.1016/j.tvjl.2017.11.008
Abstrakt: This study investigated familial relationships among Deutsch Drahthaar dogs with craniomandibular osteopathy and examined the most likely mode of inheritance. Sixteen Deutsch Drahthaar dogs with craniomandibular osteopathy were diagnosed using clinical findings, radiography or computed tomography. All 16 dogs with craniomandibular osteopathy had one common ancestor. Complex segregation analyses rejected models explaining the segregation of craniomandibular osteopathy through random environmental variation, monogenic inheritance or an additive sex effect. Polygenic and mixed major gene models sufficiently explained the segregation of craniomandibular osteopathy in the pedigree analysis and offered the most likely hypotheses. The SLC37A2:c.1332C>T variant was not found in a sample of Deutsch Drahthaar dogs with craniomandibular osteopathy, nor in healthy controls. Craniomandibular osteopathy is an inherited condition in Deutsch Drahthaar dogs and the inheritance seems to be more complex than a simple Mendelian model.
(Copyright © 2017 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: