Vitamin D Deficiency in Ambulant Children on Carbamazepine or Sodium Valproate Monotherapy.

Autor: Sreedharan M; Departments of Pediatric Neurology, Government Medical College, Thiruvananthapuram, India., Devadathan K; Departments of Pediatric Neurology, Government Medical College, Thiruvananthapuram, India. Correspondence to: Dr Kalpana Devadathan, Additional Professor, Department of Pediatric Neurology, Government Medical College, Thiruvananthapuram, Kerala, India. vijaykalpana10@gmail.com., Mohammed Kunju PA; Departments of Pediatric Neurology, Government Medical College, Thiruvananthapuram, India., Sasidharan B; Departments of Pediatrics, Government Medical College, Thiruvananthapuram, India., Pillai JP; Departments of Biochemistry; Government Medical College, Thiruvananthapuram, India., Vasumathy Amma MA; Departments of Biochemistry; Government Medical College, Thiruvananthapuram, India., Muthubeevi S; Departments of Biochemistry; Government Medical College, Thiruvananthapuram, India.
Jazyk: angličtina
Zdroj: Indian pediatrics [Indian Pediatr] 2018 Apr 15; Vol. 55 (4), pp. 307-310. Date of Electronic Publication: 2018 Feb 09.
Abstrakt: Objective: To assess the effect of monotherapy with Carbamazepine (CBZ) and Sodium valproate (VPA) on serum 25-OH Vitamin D levels in children with epilepsy compared to controls.
Design: Cross-sectional study.
Setting: Outpatient department of a tertiary-care Pediatric Neurology centre, and a nearby day-care centre and school.
Study Period: June 2012 to May 2013.
Participants: Children with epilepsy aged 2 to 13 years on monotherapy with CBZ (n=28) or VPA (n=28) for at least 6 months; 109 age-matched controls from a nearby day-care centre and school.
Results: The median (IQR) values of 25 (OH) vitamin D was 18.0 ng/mL (13.7-27.3), 21.35 ng/mL (16.4 -25.2) and 30.5 ng/mL (19.1-43.7) in CBZ, VPA and control group, respectively (P= 0.008). 60.7% of patients in CBZ group and 35.7 % in VPA group had low 25 (OH) D levels (%20 ng/mL) compared to 27.8% in controls (P=0.001).The serum alkaline phosphatase level was higher in children on carbamazepine therapy (P=0.001) than controls.
Conclusion: This study identifies significant risk of vitamin D deficiency in ambulant children with epilepsy on monotherapy with CBZ or VPA.
Databáze: MEDLINE
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