Giant Cell Tumor of Bone in Patients 55 Years and Older: A Study of 34 Patients.

Autor:	Broehm CJ; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN., Inwards CY; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN., Al-Ibraheemi A; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN., Wenger DE; Department of Radiology, Mayo Clinic, Rochester, MN., Jenkins SM; Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN., Jin L; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN., Oliveira AM; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN., Zreik RT; Department of Pathology, Baylor Scott & White Health, Temple, TX., Carter JM; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN., Boland JM; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN., Fritchie KJ; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
Jazyk:	angličtina
Zdroj:	American journal of clinical pathology [Am J Clin Pathol] 2018 Feb 17; Vol. 149 (3), pp. 222-233.
DOI:	10.1093/ajcp/aqx155
Abstrakt:	Objectives: Most giant cell tumors of bone (GCTs) occur in patients aged 20 to 40 years. We analyzed features of GCT in patients 55 years or older. Methods: GCTs were examined for fibrosis, matrix, cystic change, histiocytes, mitoses, and necrosis. Clinical/radiologic data were collected. Results: Thirty-four (5%) of 710 GCTs occurred in patients older than 55 years (14/20 male/female; 56-83 years) in long bones (n = 24), vertebrae (n = 6), pelvis (n = 3), and metacarpal (n = 1). Imaging was classic in 26 of 27 cases; one case appeared malignant. Morphologic patterns included fibrosis (n = 29), bone formation (n = 19), cystic change (n = 8), necrosis (n = 8), foamy histiocytes (n = 7), and secondary aneurysmal bone cyst formation (n = 1). Mitoses ranged from 0 to 18 per 10 high-power fields. Six recurred; one patient developed metastasis. Four of five cases harbored H3F3A mutations. Conclusions: GCTs in patients 55 years or older share pathologic characteristics with those arising in younger adults. Fibrosis and reactive bone are common, potentially leading to diagnostic confusion in this population. No histologic features correlate with adverse outcome. (© American Society for Clinical Pathology, 2018. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com)
Databáze:	MEDLINE
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