All guns blazing: management and survival of massive valproic acid overdose - case report and literature review.
| Autor: | Al Jawder S; King Hamad University Hospital, Busaiteen, Bahrain., AlJishi E; Emergency Medicine Department., Al-Otaibi S; Emergency Medicine Department., Al-Shahrani MS; Emergency and Critical Care Department, King Fahad Hospital of the University, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia. |
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| Jazyk: | angličtina |
| Zdroj: | Open access emergency medicine : OAEM [Open Access Emerg Med] 2018 Jan 25; Vol. 10, pp. 31-36. Date of Electronic Publication: 2018 Jan 25 (Print Publication: 2018). |
| DOI: | 10.2147/OAEM.S151095 |
| Abstrakt: | A 51-year-old woman, who intentionally ingested a massive dose of ~60 g of valproic acid which she was using as a mood stabilizer for bipolar affective disorder, presented within 30 minutes of ingestion to the emergency department. The patient was asymptomatic and was immediately started on decontamination therapy with activated charcoal (AC). Drug serum levels, liver functions, and ammonia levels were tested and followed up during treatment. Due to the massive ingestion and continuous rise in serum drug levels, the patient received regular multiple doses of AC, as well as l-carnitine for liver protection. The patient was started on extracorporeal therapy in the form of renal replacement therapy in the intensive care unit (ICU), followed by intermittent hemodialysis. Drug serum levels dropped significantly. Ammonia levels showed improvement with treatment. The patient was discharged from the ICU after 14 days of treatment. She was stable and in good condition with no residual hepatic or central nervous system (CNS) manifestations. Competing Interests: Disclosure The authors report no conflicts of interest in this work. |
| Databáze: | MEDLINE |
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